Skip to main content

Table 2 Results of the subdistribution hazard regression (Fine and Gray) models for both type of failures

From: Front-line intraperitoneal versus intravenous chemotherapy in stage III-IV epithelial ovarian, tubal, and peritoneal cancer with minimal residual disease: a competing risk analysis

 

Unadjusted

Adjustedc

Patient categories

SDHR (95 % CI)b

P value

SDHR (95 % CI)b

P value

CSM

 Agea

0.96 (0.75–1.23)

0.121

0.95 (0.67–1.35)

0.132

 Stage

    

  III

1

 

1

 

  IV

2.43 (1.58–3.73)

0.026

2.66 (1.47–4.81)

0.021

 Grade

    

  1

1

 

1

 

  2

1.24 (0.97–1.59)

0.037

1.36 (0.99–1.94)

0.088

  3

1.57 (1.03–2.39)

0.024

1.89 (1.04–3.43)

0.031

 Histology

    

  Serous

1

 

1

 

  Mucinous

0.93 (0.82–1.05)

0.095

0.95 (0.79–1.14)

0.118

  Clear cell

1.43 (1.02–2.01)

0.036

1.68 (1.14–2.48)

0.029

  Endometrioid

0.96 (0.82–1.12)

0.102

0.98 (0.89–1.07)

0.095

  Othersd

2.17 (1.65–2.85)

0.028

2.36 (1.67–3.34)

0.025

 Type of chemotherapy

    

  intravenous

1

 

1

 

  intraperitoneal

0.78 (0.67–0.91)

0.029

0.82 (0.70–0.96)

0.031

 GOG performance status

    

   ≤ 1

1

 

1

 

   ≥ 2

0.83 (0.68–1.02)

0.075

0.92 (0.81–1.06)

0.079

 Charlson comorbidity index

    

  0

1

 

1

 

   ≥ 1

0.84 (0.68–1.04)

0.083

0.88 (0.70–1.09)

0.089

OCM

 Agea

0.95 (0.91–0.99)

0.038

0.92 (0.87–0.97)

0.017

 Stage

    

  III

1

 

1

 

  IV

0.92 (0.77–1.11)

0.337

0.87 (0.69–1.04)

0.214

 Grade

    

  1

1

 

1

 

  2

0.87 (0.65–1.16)

0.298

0.91 (0.64–1.29)

0.348

  3

0.92 (0.59–1.47)

0.361

0.87 (0.55–1.37)

0.229

 Histology

    

  Serous

1

 

1

 

  Mucinous

1.06 (0.89–1.26)

0.139

1.07 (0.85–1.35)

0.168

  Clear cell

1.01 (0.76–1.18)

0.106

1.05 (0.86–1.28)

0.143

  Endometrioid

0.95 (0.82–1.10)

0.295

0.98 (0.79–1.21)

0.315

  Othersd

0.91 (0.81–1.02)

0.082

0.89 (0.75–1.05)

0.091

 Type of chemotherapy

    

  Intravenous

1

 

1

 

  Intraperitoneal

0.89 (0.73–1.22)

0.127

0.94 (0.81–1.09)

0.115

 GOG performance status

    

   ≤ 1

1

 

1

 

   ≥ 2

1.05 (0.84–1.38)

0.229

1.03 (0.82–1.36)

0.226

 Charlson comorbidity index

    

  0

1

 

1

 

   ≥ 1

0.77 (0.65–0.92)

0.022

0.79 (0.66–0.94)

0.027

  1. Abbreviations CSM cancer-specific mortality, OCM other-cause mortality, CI confidence interval
  2. aper 10 year increment in age
  3. bSDHR denotes subdistribution hazards ratio obtained by Fine-Gray model. CI, confidence interval
  4. cAdjusted for the following factors: age, stage, nuclear grade, histologic subtype, type of chemotherapy
  5. d“Others” histology includes mixed type, undifferentiated, and carcinosarcoma