Fig. 6From: RETRACTED ARTICLE: CDK4 and miR-15a comprise an abnormal automodulatory feedback loop stimulating the pathogenesis and inducing chemotherapy resistance in nasopharyngeal carcinomamiR-15a modulated cell cycle signaling in NPC. a. miR-15a mimics decreased the expression of key cell cycle transition factors including c-Myc, CCND1,CDK4, and E2F1. b. Luciferase reporter assay was used to determine miR-15a directly targeting the 3′UTR of CCND1. (*P < 0.05)Back to article page