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Table 3 Stratified analysis of pooled harazd ratios of lactate dehydrogenase on progression free survival

From: The prognostic value of lactate dehydrogenase levels in colorectal cancer: a meta-analysis

    Pooled HR (95 % CI)   Heterogeneity
Stratified analysis No. of studies No. of patients Fixed Random Meta-regression on p-value I2 (%) p-value
Study location      0.196   
 Asia 2 418 1.60 [1.33, 1.93] 3.20 [0.63,16.27]   93.8 <0.001
 Europe 6 1359 0.87 [0.71, 1.08] 1.15 [0.65, 2.04]   74.4 0.002
Number of patients      0.762   
 ≥100 4 1483 1.16 [1.00, 1.34] 1.26 [0.72, 2.19]   89.5 <0.001
 <100 5 330 1.00 [1.001, 1.004] 1.59 [0.64, 3.98]   86.3 <0.002
Chemotherapy with anti-angiogenesis drugs      0.717   
 Yes 6 1422 1.00 [1.001, 1.004] 1.36 [0.96, 1.98]   90.6 <0.001
 No 2 295 1.56 [1.06, 2.33] 1.80 [0.86, 3.80]   41.9 0.19
Risk of bias      0.805   
 High 6 738 1.00 [1.001, 1.004] 1.51 [1.01, 2.25]   89.1 <0.001
 Low 3 1075 0.74 [0.57, 0.95] 1.31 [0.49, 3.53]   805 0.006