Table 3 Stratified analysis of pooled harazd ratios of lactate dehydrogenase on progression free survival

Study location

0.196

 Asia

2

418

1.60 [1.33, 1.93]

3.20 [0.63,16.27]

93.8

<0.001

 Europe

6

1359

0.87 [0.71, 1.08]

1.15 [0.65, 2.04]

74.4

0.002

Number of patients

0.762

 ≥100

4

1483

1.16 [1.00, 1.34]

1.26 [0.72, 2.19]

89.5

<0.001

 <100

5

330

1.00 [1.001, 1.004]

1.59 [0.64, 3.98]

86.3

<0.002

Chemotherapy with anti-angiogenesis drugs

0.717

 Yes

6

1422

1.00 [1.001, 1.004]

1.36 [0.96, 1.98]

90.6

<0.001

 No

2

295

1.56 [1.06, 2.33]

1.80 [0.86, 3.80]

41.9

0.19

Risk of bias

0.805

 High

6

738

1.00 [1.001, 1.004]

1.51 [1.01, 2.25]

89.1

<0.001

 Low

3

1075

0.74 [0.57, 0.95]

1.31 [0.49, 3.53]

805

0.006