Skip to main content

Table 2 Stratified analysis of pooled hazard ratios of lactate dehydrogenase on overall survival

From: The prognostic value of lactate dehydrogenase levels in colorectal cancer: a meta-analysis

    Pooled HR (95 % CI)   Heterogeneity
Stratified analysis No. of studies No. of patients Fixed Random Meta-regression on p-value I2 (%) p-value
Study location      0.581   
 Asia 4 580 1.66 [1.29, 2.14] 1.82 [1.14, 2.9]   67.9 0.025
 Europe 19 5276 1.66 [1.53, 1.80] 1.67 [1.40, 2.0]   69.5 <0.001
 Other regions 5 1065 1.85 [1.52, 2.25] 2.07 [1.45, 2.94]   64.1 0.025
Age      0.563   
  ≤ 50 2 191 1.98 [1.33, 2.94] 2.31 [1.04, 5.13]   63.1 0.1
 No limitation 22 5623 1.70 [1.57, 1.84] 1.77 [1.51, 2.08]   68.5 <0.001
Number of patients      0.68   
  ≥ 100 22 6428 1.68 [1.56, 1.81] 1.73 [1.49, 2.01]   69 <0.001
  < 100 6 439 1.84 [1.66, 2.04] 1.96 [1.11, 3.43]   60.3 0.28
Metastasis      0.059   
 Yes 16 5044 1.84 [1.66, 2.04] 1.96 [1.61, 2.37]   64.4 <0.001
 No 5 883 1.53 [1.29, 1.82] 1.21 [0.79, 1.86]   74.4 0.028
LDH cutoff      0.309   
  > 300 U/L 7 764 1.93 [1.50, 2.49] 1.98 [1.41, 2.77]   29.1 0.206
 250–300 U/L 5 1028 1.61 [1.38, 1.88] 1.84 [1.08, 3.13]   88.6 <0.001
  < 250 U/L 6 1174 1.58 [1.31, 1.90] 1.44 [0.94, 2.21]   75.4 0.001
Chemotherapy with anti-angiogenesis drugs      0.64   
 Yes 5 1675 1.75 [1.51, 2.02] 1.78 [1.41, 2.23]   57.3 0.053
 No 16 4166 1.60 [1.46, 1.75] 1.65 [1.40, 1.94]   54.8 0.003
Study type      0.863   
 non-RCTa 22 3683 1.66 [1.51, 2.02] 2.03 [1.31, 3.13]   71.5 <0.001
 RCT 5 3238 1.73 [1.54, 1.94] 1.73 [1.54, 1.94]   <0.01 0.535
Risk of bias      0.31   
 High 16 3142 1.52 [1.36, 1.68] 1.63 [1.28, 2.09]   76.5 <0.001
 Low 11 3799 1.87 [1.69, 2.07] 1.65 [1.28, 2.12]   <0.01 0.655
  1. anon-RCT includes PSCS, RMCS and RSCS groups