Table 1 GeneGO pathway maps significantly enriched for both up- and down-regulated genes in MCF-7-Snail vs MCF-7-Control cells (FDR = 0.06089); P/T – differentially expressed genes mapped to a given map/total number of genes in a map
# | Pathway map | p-value | FDR | P/T |
|---|---|---|---|---|
1 | Chemotaxis_C5a-induced chemotaxis | 6.298E-05 | 3.136E-02 | 21/27 |
2 | ENaC regulation in normal and CF airways | 7.539E-05 | 3.136E-02 | 26/36 |
3 | Development_TGF-beta-dependent induction of EMT via SMADs | 1.394E-04 | 3.865E-02 | 25/35 |
4 | Development_Thromboxane A2 signaling pathway | 2.847E-04 | 5.199E-02 | 25/36 |
5 | Muscle contraction_Relaxin signaling pathway | 3.125E-04 | 5.199E-02 | 26/38 |
6 | Ca(2+)-dependent NF-AT signaling in cardiac hypertrophy | 5.485E-04 | 5.627E-02 | 25/37 |
7 | Main growth factor signaling cascades in multiple myeloma cells | 5.485E-04 | 5.627E-02 | 25/37 |
8 | Cytoskeleton remodeling_RalA regulation pathway | 5.733E-04 | 5.627E-02 | 19/26 |
9 | Regulation of CFTR activity (normal and CF) | 6.448E-04 | 5.627E-02 | 28/43 |
10 | Signal transduction_Calcium signaling | 8.247E-04 | 5.627E-02 | 22/32 |
11 | Apoptosis and survival_HTR1A signaling | 1.003E-03 | 5.627E-02 | 25/38 |
12 | Development_A1 receptor signaling | 1.003E-03 | 5.627E-02 | 25/38 |
13 | Transcription_CREB pathway | 1.045E-03 | 5.627E-02 | 26/40 |
14 | Transport_Clathrin-coated vesicle cycle | 1.054E-03 | 5.627E-02 | 40/68 |
15 | PTMs in IL-17-induced CIKS-independent signaling pathways | 1.079E-03 | 5.627E-02 | 27/42 |
16 | Signal transduction_Activation of PKC via G-Protein coupled receptor | 1.107E-03 | 5.627E-02 | 28/44 |
17 | Apoptosis and survival_Endoplasmic reticulum stress response pathway | 1.150E-03 | 5.627E-02 | 31/50 |
18 | Development_Hedgehog and PTH signaling pathways in bone and cartilage development | 1.345E-03 | 6.089E-02 | 20/29 |