Fig. 6
From: Epigenetic silencing of miR-181c by DNA methylation in glioblastoma cell lines
Two chromatin loops flank miR-181c in GM12878 cells. a Screenshot from JuiceBox in situ Hi-C data display of GM12878 cell line at 5 kb resolution. Yellow triangles represent chromatin loops. MiR-181c is represented by an arrow. Note that miR-181c as well as its promoter and CTCF proximal binding site are located in the transition between two chromatin loops. Left loop, chr19: 13855001–13975000; Right loop, chr19: 13990001–14185000. b IGV genome browser screenshot for ChIP-seq data of CTCF in 12 different cell lines. Signal tracks are displayed for each cell line. Two constitutive binding sites of CTCF flank the dynamic CTCF binding site for miR-181C. The constitutive sites correspond to the anchors of the chromatin loops as shown in (a). Data downloaded from the Analysis Data hub by the ENCODE project. c Model of two chromatin loops flanking miR-181c