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Fig. 4 | BMC Cancer

Fig. 4

From: Honokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/STAT signaling pathway suppression and apoptosis induction

Fig. 4

Honokiol inhibits colony formation and induces apoptosis via Bax/Bcl-2 and caspase-3-dependent pathway in SP-derived sphere cells. a Honokiol inhibited colony formation of the SAS and OECM-1 SP-derived sphere cells in a dose-dependent manner. The colony formation data are expressed as percent of control (without honokiol treatment) cells and shown as mean ± SD. *p < 0.05; **p < 0.01, significant difference vs. control. b Honokiol induced apoptosis of the SAS and OECM-1 SP-derived spheres in a dose-dependent manner. Apoptosis was determined by Annexin V-FITC/PI double staining and flow cytometry analysis. The honokiol concentration is shown in the right side of dot plots. The numbers in LR (lower right) quadrant indicates the percentage of early apoptotic cells. The numbers in UR (upper right) quadrant indicates the percentage of late apoptotic cells. c Dose-dependent effect of honokiol on the protein levels of Bax and Bcl-2. d Dose-dependent effect of honokiol on cleavage of caspase-3

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BMC Cancer

ISSN: 1471-2407

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