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Table 3 List of ROHs associated with TC

From: Runs of homozygosity and inbreeding in thyroid cancer

ROH Chr. Start – End (bp)a Cases/controls Chi2 P b P c iHS maxd Fst max e Fay and Wu’s Hf Genesg
ROH1 2 167204846–167895993 6 / 15 8,87 0.002 1.44 × 10−4 3.50 0.50 −74.64 XIRP2
ROH2 3 121016843–121689105 10 / 0 6,70 0.009 9.43 × 10−6 2.76 0.50 −37.03 GSK3B, FSTL1, LRRC58, GPR156
ROH3 10 44969326–45928700 5 / 11 5,63 0.01 6.12 × 10−5 1.85 0.35 −57.08 ALOX5, OR13A1, ANUBL1, CTGLF1, MARCH8, OR6D1P, FAM21C, CTGLF10P
ROH4 6 69734043–70381283 2 / 7 5,42 0.01 0.007 2.58 0.27 −31.48 BAI3g
ROH5 9 73966521–74829925 2 / 7 5,42 0.01 1.60 × 10−12 2.05 0.44 −19.76 ALDH1A1, ZFAND5, TMC1
ROH6 1 217208583–218034929 7 / 0 4,67 0.03 0.08 2.17 0.41 −55.42 LYPLAL1, ZC3H11B
ROH7 2 26036646–26765583 7 / 0 4,67 0.03 0.18 2.42 0.61 −64.28 HADHA, HADHB, OTOF, RAB10, SELI, C2orf39, CIB4, FAM59B, PPIL1P1, GPR113, C2orf70
ROH8 2 75174688–76481471 7 / 0 4,67 0.03 0.03 2.78 0.57 −66.54 C2orf3, MRPL19, FAM176A,
ROH9 1 177243354–178385972 6 / 0 4,00 0.04 1.67 × 10−4 2.67 0.38 −56.96 ABL2, SOAT1, NPHS2, CEP350, FAM20B, TOR1AIP1, IFRG15, TOR3A, C1orf125, FAM163A, TDRD5, TOR1AIP2
ROH10 2 112182736–113192306 6 / 0 4,00 0.04 0.02 2.54 0.41 −24.47 SLC20A1, MERTK, ANAPC1, POLR1B, CHCHD5, ZC3H8, TMEM87B, FBLN7, TTL, ZC3H6, RGPD8,
ROH11 2 113858688–114678121 6 / 0 4,00 0.04 0.83 2.37 0.50 −48.23 ACTR3, RABL2A, SLC35F5, RPL23AP7, CBWD2, RP11-395 L14.12, FOXD4L1, WASH2P
ROH12 4 181001922–181547116 6/ 0 4,00 0.04 0.33 2.29 0.53 −36.74 NA
ROH13 4 182307562–182564832 6 / 0 4,00 0.04 0.35 2.09 0.30 −31.12 hCG_2025798
ROH14 4 183848547–184539543 6 / 0 4,00 0.04 1.00 × 10−8 2.09 0.65 −56.96 DCTD, CLDN22, WWC2, C4orf38, FAM92A3, CLDN24
ROH15 9 107008151–108187183 6 / 0 4,00 0.04 0.51 2.75 0.58 −46.35 FKTN, TAL2, SLC44A1, GARNL2P, TMEM38B, FSD1L, DEPDC1P2
ROH16 15 96502627–98965249 6 / 0 4,00 0.04 3.01 × 10−12 3.09 0.65 −110.70 IGF1R, MEF2A, HSP90B2P, SYNM, LINS1, TTC23, LRRC28, LYSMD4, ADAMTS17, C15orf51, LASS3, FAM169B, FLJ42289, PRKXP1
  1. aChromosomal positions derived from the National Center for Biotechnology Information (NCBI), build 36, hg18
  2. bSuggestive significance
  3. cSignificances for testing differences in homozygosity with H0 : μCases = μControls; H1 : μCases > μControls;
  4. dRepresents maximal absolute values for iHS, derived for CEU population ancestry from Haplotter, Phase II (http://haplotter.uchicago.edu/)
  5. eRepresents maximal values for Fst, derived for CEU population ancestry from Haplotter, Phase II
  6. fRepresents minimum values for Fay and Wu’s H, derived for CEU population ancestry from Haplotter, Phase II
  7. gin flanking region