Table 5 Gene ontology enrichment in different groups of hereditary tumors
Tumor groups | Enriched Gene Ontologies |
|---|---|
BRCA1/2 mutated | Regulation of cytoskeleton organization, Negative regulation of mammary epithelial cell proliferation, Protein modification process, Apoptosis, Cell cycle regulation, RNA transcription and processing, DNA damage repair, DNA packaging |
BRCA1 not expressing | Alpha aminoacid metabolic/biosynthetic processes, Protein citrullination and Citrulline metabolism, Proteolysis, Transcription, Chromosome segregation and chromatin organization, Apoptosis |
BRCA1 expressing | No enrichment was found |
Blue cluster | Antigen processing and presentation (13 GO Terms), Intracellular transport |
Yellow cluster | Cytokine signaling, Collagen metabolic processes and Extracellular matrix organization |
Purple cluster | Calcium-independent cell-cell adhesion |
Green cluster | No enrichment was found |