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Table 4 Genomic deletions and gains shared by 2 or more germline mutated tumors

From: Different Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival

  BRCA2 mutated tumors BRCA1 mutated tumors
Mutation 1 Mutation 2 Mutation 3 Mutation 4
Chr region Start Stop Size bp Genes T50 T5 T51 T44 T49 T24 T25
1q41 212228277 212570219 341942 PROX1, SMYD2   Loss   Loss    
2p25.1 11198066 11682912 484846 PQLC3, ROCK2, E2F6, GREB1     Gain   Gain  
2q33.1 197759971 197921182 161211 ANKRD44     Loss   Loss  
2q33.2 203984291 204102868 118577 ABI2, RAPH1 Loss Loss     Loss  
4q32.3-4q33 167949877 170912917 2963040 SPOCK3, ANXA10, DDX60, PALLD, CBR4, SH3RF1, NEK1, CLCN3 Loss Loss      
4q34.1-4q34.2 175832063 176792165 960102 GLRA3, ADAM29, GMP6A Loss      Loss  
7p13 43308108 44125072 816964 HECW1, STK17A, BLVRA, MRPS24, URG4, UDE2D4, DBNL, PGAM2, POLM, AEBP1, POLD2   Loss   Loss    
11q12.1 58254147 58647789 393642 GLYAT, GLYATL2, GLYATL1 Loss Loss      
17q21.2 38450905 38521318 70413 BRCA1     Loss Loss Loss  
17q23.2 57344164 57454012 109848 INTS2, MED13   Loss    Loss   
19q13.11 40168316 40221937 53621 GRAMD1A, SCN1B Loss     Loss   
20q13.12 44813919 45159168 345249 EYA2 Loss    Loss Loss   
  1. In bold are highlighted cancer associated genes found in genomic losses and gains present only in BRCA1 and BRCA2 tumors