Table 3 Genomic gains found in more than 10Â % of BRCAX breast tumors
Chromosome | CytoBand | Start | Stop | Size bp | Percentage of BRCAX tumors (N = 40) | Candidate oncogenes | Other genes |
|---|---|---|---|---|---|---|---|
1 | q21.1 | 143706304 | 143905470 | 199,166 | 15.0 | PDE4DIP | SEC22B |
q21.1 | 144219515 | 144279910 | 60,395 | 12.5 | RBM8A | GNRHR2, PEX11B, ITGA10, ANKRD35 | |
q21.2 | 148240535 | 148367347 | 126,812 | 12.5 | OTUD7B | VPS45 | |
q21.2 | 148392365 | 148504936 | 112,571 | 17.5 | Â | PLEKHO1, APH1A, ANP32E, CA14 | |
q21.2 | 148519890 | 148564234 | 44,344 | 15.0 | Â | C1orf54, C1orf51, MRPS21, PRPF3 | |
q32.1 | 201456918 | 201966787 | 509,869 | 12.5 | BTG2 | CHIT1, FMOD, ATP2B4 | |
q32.1 | 202269067 | 202358437 | 89,370 | 12.5 | Â | C1orf157, SOX13 | |
q32.1 | 205037481 | 205260296 | 222,815 | 15.0 | IL19, IL20, FAIM3 | IL24, PIGR, FCAMR, C1orf116 | |
q32.2 | 205762617 | 206263053 | 500,436 | 12.5 | CD46, PLXNA2 | CR1, CR1L, CD34 | |
q32.2 | 207826895 | 208566054 | 739,159 | 12.5 | TRAF3IP3,LAMB3 | G0S2, HSD11B1, C1orf74, IRF6, C1orf107, SYT14, SERTAD4 | |
q41 | 213425725 | 213768607 | 342,882 | 12.5 | Â | KCNK2 | |
q42.12 | 223406336 | 224419278 | 1,012,942 | 12.5 | ENAH, LBR | DNAH14, SRP9, EPHX1, TMEM63A, LEFTY1, PYCR2, LEFTY2, C1orf55, H3F3A, ACBD3 | |
q42.13 | 225961050 | 226071970 | 110,920 | 12.5 | Â | JMJD4, SNAP47, MPN2 | |
6 | p21.33 | 31663820 | 31905687 | 241,867 | 12.5 | CLIC1, CSNK2B | LST1, NCR3, AIF1, BAT2, BAT3, APOM, BAT4, C6orf47, LY6G5B, LY6G5C, BAT5, LY6G6F, LY6G6E, LY6G6D, LY6G6C, DDAH2, MSH5, C6orf27, VARS, LSM2, HSPA1A, HSPA1B |
8 | q22.1 | 98923270 | 99014727 | 91,457 | 12.5 | LAPTM4B | MATN2 |
q22.3 | 104310836 | 104453937 | 143,101 | 12.5 | FZD6, CTHRC1 | BAALC | |
q23.1 | 107173263 | 107833235 | 659,972 | 12.5 | Â | OXR1 | |
q24.13 | 124926272 | 125341753 | 415,481 | 12.5 | Â | FER1L6 | |
q24.21 | 130632541 | 130857683 | 225,142 | 12.5 | Â | GSDMC | |
12 | q13.2 | 54405492 | 54500555 | 95,063 | 12.5 | CIP29 | CD63, GDF11, ORMDL2 |
17 | q12 | 34260921 | 34473439 | 212,518 | 12.5 | RPL23, PLXDC1, LASP1 | FBXO47 |
19 | q13.33 | 55918797 | 56055048 | 136,251 | 12.5 | KLK15, KLK3 | CLEC11A, GPR32, ACPT, C19orf48, KLK1 |
q13.42 | 60568830 | 60853735 | 284,905 | 12.5 | IL11, UBE2S | TMEM190, RPL28, ZNF579, FIZ1, ZNF524, ZNF580, ZNF581, CCDC106 | |
20 | q12 | 39100100 | 39358266 | 258,166 | 15.0 | PLCG1, TOP1 | PRO0628, ZHX3 |