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Table 3 Genomic gains found in more than 10 % of BRCAX breast tumors

From: Different Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival

Chromosome CytoBand Start Stop Size bp Percentage of BRCAX tumors (N = 40) Candidate oncogenes Other genes
1 q21.1 143706304 143905470 199,166 15.0 PDE4DIP SEC22B
q21.1 144219515 144279910 60,395 12.5 RBM8A GNRHR2, PEX11B, ITGA10, ANKRD35
q21.2 148240535 148367347 126,812 12.5 OTUD7B VPS45
q21.2 148392365 148504936 112,571 17.5   PLEKHO1, APH1A, ANP32E, CA14
q21.2 148519890 148564234 44,344 15.0   C1orf54, C1orf51, MRPS21, PRPF3
q32.1 201456918 201966787 509,869 12.5 BTG2 CHIT1, FMOD, ATP2B4
q32.1 202269067 202358437 89,370 12.5   C1orf157, SOX13
q32.1 205037481 205260296 222,815 15.0 IL19, IL20, FAIM3 IL24, PIGR, FCAMR, C1orf116
q32.2 205762617 206263053 500,436 12.5 CD46, PLXNA2 CR1, CR1L, CD34
q32.2 207826895 208566054 739,159 12.5 TRAF3IP3,LAMB3 G0S2, HSD11B1, C1orf74, IRF6, C1orf107, SYT14, SERTAD4
q41 213425725 213768607 342,882 12.5   KCNK2
q42.12 223406336 224419278 1,012,942 12.5 ENAH, LBR DNAH14, SRP9, EPHX1, TMEM63A, LEFTY1, PYCR2, LEFTY2, C1orf55, H3F3A, ACBD3
q42.13 225961050 226071970 110,920 12.5   JMJD4, SNAP47, MPN2
6 p21.33 31663820 31905687 241,867 12.5 CLIC1, CSNK2B LST1, NCR3, AIF1, BAT2, BAT3, APOM, BAT4, C6orf47, LY6G5B, LY6G5C, BAT5, LY6G6F, LY6G6E, LY6G6D, LY6G6C, DDAH2, MSH5, C6orf27, VARS, LSM2, HSPA1A, HSPA1B
8 q22.1 98923270 99014727 91,457 12.5 LAPTM4B MATN2
q22.3 104310836 104453937 143,101 12.5 FZD6, CTHRC1 BAALC
q23.1 107173263 107833235 659,972 12.5   OXR1
q24.13 124926272 125341753 415,481 12.5   FER1L6
q24.21 130632541 130857683 225,142 12.5   GSDMC
12 q13.2 54405492 54500555 95,063 12.5 CIP29 CD63, GDF11, ORMDL2
17 q12 34260921 34473439 212,518 12.5 RPL23, PLXDC1, LASP1 FBXO47
19 q13.33 55918797 56055048 136,251 12.5 KLK15, KLK3 CLEC11A, GPR32, ACPT, C19orf48, KLK1
q13.42 60568830 60853735 284,905 12.5 IL11, UBE2S TMEM190, RPL28, ZNF579, FIZ1, ZNF524, ZNF580, ZNF581, CCDC106
20 q12 39100100 39358266 258,166 15.0 PLCG1, TOP1 PRO0628, ZHX3
  1. Most frequent gains in BRCAX tumors are highlighted in bold