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Table 2 Genomic losses found in more than 10 % of BRCAX breast tumors

From: Different Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival

Chromosome CytoBand Start Stop Size bp Percentage of BRCAX tumors (N = 40) Candidate tumor suppressor genes Other genes
1 p31.1 78765816 79106841 341,025 12.5   PTGFR, IFI44L, IFI44
q21.2 148392365 148504936 112,571 22.5 PLEKHO1, APH1A ANP32E, CA14
q24.2 167969938 168079511 109,573 12.5   C1orf156, C1orf112
3 q25.1 152529936 152650652 120,716 12.5   MED12L,P2RY13, P2RY12, IGSF10
6 p21.32 32897974 32905723 7749 15.0   TAP2
p21.32 32918832 32929682 10,850 17.5 PSMB8 TAP1
p21.32 32932575 33057062 124,487 15.0 HLA-DMB PSMB9, BRD2
p22.1 27200902 27210109 9207 20.0   HIST1H2BJ, HIST1H2AG
7 q34 141051502 141137338 85,836 17.5 SSBP1 WEE2, TAS2R3, TAS2R4, TAS2R5
9 q32 116094655 116176804 82,149 15.0   COL27A1, ORM1, ORM2, AKNA
11 q23.3 114614479 116165823 1,551,344 15.0 CADM1 BUD13, ZPR1, APOA5
12 q13.2 54429832 54500555 70,723 12.5   GDF11, CIP29, ORMDL2
13 q21.1 52406170 52944596 538,426 12.5   OLFM4
14 q11.2 22424322 22467920 43,598 15.0   REM2, RBM23, PRMT5
15 q11.2 20477397 20599137 121,740 15.0 CYFIP1 NIPA2, NIPA1
16 q12.1 50773858 51032886 259,028 15.0   TOX3
17 q25.1 68713135 68845671 132,536 20.0   COG1, FAM104A, C17orf80, CDC42EP4, SDK2
20 q12 39100100 39142168 42,068 22.5   TOP1
q12 39201874 39331155 129,281 12.5   PLCG1, ZHX3
22 q11.21 19683237 19692296 9059 12.5   LZTR1, THAP7
  1. Most frequent losses in BRCAX tumors are highlighted in bold