Fig. 2

Cluster analysis of hereditary tumors. a Unsupervised hierarchical clustering for hereditary breast tumors. T1, T36, T22 and T29 were removed from the cluster as considered outliers. Numbers in the Y- axis correspond to each chromosome and the marks in the Y-axis are the limits between chromosomes. Green boxes: losses, Red boxes: gains, Black boxes: no change. Four groups were identified and labeled with Blue, Yellow, Green and Purple lines under the picture. In addition, ER, HER2 and BRCA1 expression status is indicated below as follows: black: positive, grey: negative, white: no information. b Overall survival of the 4 clusters determined by Log-rank (Mantel-Cox) Test, p < 0.05. Tumors from each cluster are represented with a respective color line