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Table 2 Lymphatic vessel density (LVD) and lymph node metastasis (LNM) of the orthotopic xenograft tumors in nude mice

From: TNF-alpha promotes lymphangiogenesis and lymphatic metastasis of gallbladder cancer through the ERK1/2/AP-1/VEGF-D pathway

 

Unstimulation

TNF-α (2 μg/kg)

 

LVD

LNM

LVD

LNM

control

11.73 ± 2.28

3/5

23.73 ± 2.17*

5/5

LV-siNC

14.27 ± 1.36

2/5

23.20 ± 2.18*

4/5

LV-siVEGF-D

5.67 ± 1.25

1/5

10.07 ± 1.83*

2/5

  1. *P < 0.05