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Table 2 Lymphatic vessel density (LVD) and lymph node metastasis (LNM) of the orthotopic xenograft tumors in nude mice

From: TNF-alpha promotes lymphangiogenesis and lymphatic metastasis of gallbladder cancer through the ERK1/2/AP-1/VEGF-D pathway

  Unstimulation TNF-α (2 μg/kg)
  LVD LNM LVD LNM
control 11.73 ± 2.28 3/5 23.73 ± 2.17* 5/5
LV-siNC 14.27 ± 1.36 2/5 23.20 ± 2.18* 4/5
LV-siVEGF-D 5.67 ± 1.25 1/5 10.07 ± 1.83* 2/5
  1. *P < 0.05