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Table 3 Effect of PA intervention on HRQoL FACT-B and blood biomarker variables

From: Randomised controlled trial of a home-based physical activity intervention in breast cancer survivors

   

Within-group change at follow−up

Adjusted between-group change at follow−up

 

Baseline mean (SD)

Follow-up mean (SD)

Mean change (95 % CI)

Mean change (95 % CI)

ES

p-value

FACT-B

      

 Intervention

108.56 (21.97)

114.41 (21.48)

5.91 (1.88 to 9.93)

5.05 (.69 to 9.40)

.25

.024

 Usual care

114.25 (18.97)

115.34 (17.57)

.56 (−3.43 to 4.56)

Reference

  

FACT-G

      

 Intervention

85.75 (17.35)

88.03 (18.53)

2.62 (−2.72 to 7.96)

2.17 (−1.43 to 5.78)

.14

.234

 Usual care

89.30 (13.23)

89.59 (16.84)

−.09 (−5.65 to 5.46)

Reference

  

TOI

      

 Intervention

65.29 (15.09)

72.59 (15.13)

7.20 (4.47 to 9.93)

5.64 (2.33 to 8.95)

.39

.001

 Usual care

71.13 (13.07)

73.25 (16.52)

2.13 (−1.89 to 6.14)

Reference

  

PWB

      

 Intervention

22.03 (5.25)

25.54 (9.32)

3.43 (.58 to 6.29)

.63 (−.87 to 2.13)

.13

.404

 Usual care

23.03 (4.39)

25.84 (9.18)

2.84 (−.15 to 5.84)

Reference

  

SWB

      

 Intervention

24.35 (4.44)

23.70 (5.03)

−.54 (−1.40 to .32)

−.73 (−2.03 to .59)

.17

.276

 Usual care

23.40 (4.19)

24.13 (4.13)

.19 (−1.00 to 1.37)

Reference

  

EWB

      

 Intervention

18.93 (4.61)

20.11 (4.14)

1.24 (.46 to 2.03)

.20 (−.85 to 1.26)

.05

.701

 Usual care

19.73 (3.74)

20.72 (3.30)

1.00 (.20 to 1.80)

Reference

  

FWB

      

 Intervention

20.45 (6.10)

21.95 (4.41)

1.76 (.21 to 3.30)

1.90 (.24 to 3.55)

.36

.025

 Usual care

23.15 (3.94)

22.88 (4.70)

−.16 (−1.25 to .94)

Reference

  

BCS

      

 Intervention

22.81 (6.67)

25.24 (7.13)

2.15 (.98 to 3.32)

2.84 (.79 to 4.89)

.42

.007

 Usual care

24.95 (6.79)

24.34 (6.21)

−75 (−2.81 to 1.31)

Reference

  

TC (mmol∙L−1)

      

 Intervention

5.75 (1.30)

5.4 (1.09)

−.23 (−.49 to .04)

−.45 (−.71 to −.18)

−.38

.001

 Usual care

5.79 (1.04)

5.93 (.91)

.22 (.05 to .38)

Reference

  

HDL (mmol∙L−1)

      

 Intervention

1.65 (.30)

1.62 (.33)

−.02 (−.12 to 0.79)

−.06 (−.15 to .04)

−.19

.264

 Usual care

1.59 (.34)

1.60 (.30)

.04 (−.03 to .10)

Reference

  

LDL (mmol∙L−1)

      

 Intervention

3.44 (1.15)

3.18 (1.01)

−.19 (−.42 to .04)

−.30 (−.56 to −.04)

−.30

.023

 Usual care

3.56 (.84)

3.64 (.84)

.11 (−.11 to .32)

Reference

  

TC/HDL-C ratio (mmol∙L−1)

      

 Intervention

3.61 (1.12)

3.47 (.93)

−.09 (−.36 to .09)

−.13 (−.40 to .14)

−.12

.337

 Usual care

3.79 (1.00)

3.83 (.90)

.04 (−.19 to .26)

Reference

  

Trig (mmol∙L−1)

      

 Intervention

1.43 (.75)

1.31 (.58)

−.08 (−.21 to .05)

−.10 (−.27 to .07)

−.13

.240

 Usual care

1.52 (.85)

1.52 (.73)

.02 (−.14 to .18)

Reference

  

Glucose (mmol∙L−1)

      

 Intervention

4.94 (.85)

4.81 (.52)

−.14 (−.36 to .09)

−.07 (−.38 to .25)

−.05

.683

 Usual care

5.27 (1.96)

5.32 (2.20)

−.08 (−.40 to .25)

Reference

  

Insulin (pmol∙L−1)

      

 Intervention

38.37 (34.61)

37.40 (28.64)

−1.03 (15.37 to 13.31)

8.31 (−12.31 to 28.95)

.20

.425

 Usual care

45.45 (48.69)

37.34 (40.60)

−9.84 (−29.76 to 10.08)

Reference

  

HOMA

      

 Intervention

1.60 (1.18)

1.78 (.88)

.07 (−.62 to .76)

.42 (−.88 to 1.73)

.27

.520

 Usual care

2.18 (1.83)

1.90 (2.09)

−.41 (−2.09 to 1.26)

Reference

  
  1. Key: FACT-G = PWB + SWB + EWB + FWB; FACT-B = FACT-G + BCS; TOI = PWB + FWB + BCS
  2. Baseline means (SD) are based on 80 participants except for HOMA (N = 52; intervention = 27; control = 25); Post-interventions and with-group change at follow-up means (SD) are based on 70 participants (intervention = 37; control = 33), except HOMA (N = 38; Intervention = 20; control = 18)
  3. Except for the blood measures (Higher scores represent better quality of life), positive ES indicate effects in favour of the exercise intervention group
  4. Between-group effects were assessed using linear mixed model analysis including the measurements obtained at baseline and post-intervention, adjusted for the value of the outcome variable at baseline