Table 2 SNPs associated with PSE and their odds ratios relative to the control
From: A genetic variant of the NTCP gene is associated with HBV infection status in a Chinese population
SNP | Control, N = 1075(100 %) | PS, N = 1936 (100 %) | PSE, 639 (100 %) | Plinear | PSE vs Control | ||
|---|---|---|---|---|---|---|---|
P | OR | 95 % CI | |||||
rs4646287 | |||||||
CC | 843 (79.0) | 1548 (81.2) | 541 (84.9) | 0.005 | 1 | ||
CT | 215 (20.1) | 334 (17.5) | 89 (14.0) | 0.0014 | 0.65 | 0.49–0.85 | |
TT | 9 (0.8) | 25 (1.3) | 7 (1.1) | 0.705 | 1.21 | 0.45–3.27 | |
CT + TT | 224 (21.0) | 359 (18.8) | 96 (15.1) | 0.004 | 0.0026 | 0.67 | 0.51–0.87 |
C | 1901 (89.1) | 3430 (89.9) | 1171 (91.9) | 1 | |||
T | 233 (10.9) | 384 (10.1) | 103 (8.1) | 0.010 | 0.0075 | 0.72 | 0.56–0.92 |
rs2296651 | |||||||
GG | 1010 (94.7) | 1834 (95.2) | 585 (91.7) | 1 | |||
GA | 57 (5.3) | 92 (4.8) | 53 (8.3) | 0.033 | 0.017 | 1.61 | 1.09–2.37 |
G | 2077 (97.3) | 3760 (97.6) | 1223 (95.8) | 1 | |||
A | 57 (2.7) | 92 (2.4) | 53 (4.2) | 0.036 | 0.021 | 1.58 | 1.05–2.35 |
rs28437822 | |||||||
AA | 769 (72.1) | 1383 (72.2) | 470 (73.7) | 0.062 | 1 | ||
AG | 266 (25.0) | 491 (25.6) | 161 (25.2) | 0.933 | 0.99 | 0.79–1.24 | |
GG | 31 (2.9) | 41 (2.1) | 7 (1.1) | 0.018 | 0.37 | 0.16–0.85 | |
AG + GG | 297 (27.9) | 532 (27.7) | 168 (26.3) | 0.542 | 0.493 | 0.93 | 0.74–1.16 |
A | 1804 (84.6) | 3257 (85.0) | 1101 (86.3) | 1 | |||
G | 328 (15.4) | 573 (15.0) | 175 (13.7) | 0.208 | 0.195 | 0.87 | 0.71–1.07 |
rs11624523 | |||||||
AA | 766 (71.5) | 1380 (72.0) | 467 (73.7) | 0.153 | 1 | ||
AG | 272 (25.4) | 494 (25.8) | 157 (24.8) | 0.638 | 0.95 | 0.75–1.19 | |
GG | 33 (3.1) | 43 (2.2) | 10 (1.6) | 0.056 | 0.50 | 0.24–1.02 | |
AG + GG | 305 (28.5) | 537 (28.0) | 167 (26.3) | 0.372 | 0.341 | 0.90 | 0.72–1.12 |
A | 1804 (84.2) | 3254 (84.9) | 1091 (86.0) | 1 | |||
G | 338 (15.8) | 580 (15.1) | 177 (14.0) | 0.110 | 0.166 | 0.87 | 0.71–1.06 |
rs4646285 | |||||||
CC | 768 (72.2) | 1391 (72.5) | 469 (73.7) | 0.051 | 1 | ||
CT | 264 (24.8) | 486 (25.3) | 160 (25.2) | 0.948 | 0.99 | 0.79–1.25 | |
TT | 32 (3.0) | 42 (2.2) | 7 (1.1) | 0.015 | 0.36 | 0.16–0.82 | |
CT + TT | 296 (27.8) | 528 (27.5) | 174 (27.3) | 0.736 | 0.484 | 0.92 | 0.74–1.15 |
C | 1800 (84.6) | 3268 (85.1) | 1098 (86.3) | 1 | |||
T | 328 (15.4) | 570 (14.9) | 174 (13.7) | 0.182 | 0.178 | 0.87 | 0.71–1.06 |