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Table 4 Univariate and multivariate relapse-free survival analysis of patients who underwent rectal cancer resection (Cox proportional hazard model)

From: Role of autophagy-related protein expression in patients with rectal cancer treated with neoadjuvant chemoradiotherapy

 

Variable

Univariate analysis

Multivariate analysis

HR

95 % CI

P value

HR

95 % CI

P value

Age

 

0.995

0.97 – 1.03

0.777

   

Sex

Female vs. Male

0.931

0.44 – 1.97

0.852

   

cT stage

cT4 vs. cT2-3

7.920

2.33 – 27.00

<0.001

7.236

2.20 – 15.24

< 0.001

cN stage

cN1-2 vs. cN0

2.050

1.00 – 4.19

0.050

2.257

2.81 – 18.62

0.022

Histological grade

Poorly vs. Well/Mod

3.520

1.34 - 9.20

0.010

5.783

1.13 – 4.52

< 0.001

CEA

 

1

0.99 – 1.01

0.482

   

LDH

 

1

0.99 – 1.00

0.939

   

ypCR

Yes vs. Nos

0.308

0.09 –1.01

0.050

0.216

0.07 – 0.64

0.006

LC3β expression

High vs. Low

0.986

0.49 – 1.98

0.970

0.666

0.27 – 1.67

0.386

Beclin-1 expression

High vs. Low

1.070

0.52 – 2.23

0.854

1.147

0.43 – 3.09

0.786

  1. HR hazard ratio, CI confidence interval, CEA carcinoembryonic antigen, LDH lactate dehydrogenase, cT clinical T stage, cN clinical N stage, ypCR pathologic complete response