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Table 6 Standardized Mortality Ratios (SMRs) of offspring born by partners of men with a history of cancer by timing of childbirth in relation to father’s cancer diagnosis

From: Birth rates among male cancer survivors and mortality rates among their offspring: a population-based study from Sweden

 

Child born before diagnosisa

Child born around diagnosisb

Child born after diagnosisc

Overall

0.99 (0.96–1.03)

1.11 (0.75–1.53)

1.15 (0.90–1.43)

Attained Age

 0–4 yrs old

0.91 (0.86–0.97)

0.98 (0.57–1.50)

1.30 (0.97–1.66)

 5–14 yrs old

1.10 (0.96–1.24)

1.41 (0.37–3.12)

0.77 (0.24–1.59)

 15–24 yrs old

1.06 (0.97–1.16)

1.11 (0.35–2.29)

0.66 (0.24–1.29)

 25+ yrs old

1.09 (1.00–1.18)

1.57 (0.50–3.25)

1.30 (0.47–2.55)

Father's age at childbirth

 16–25 yrs old

1.03 (0.96–1.11)

0.85 (0.22–1.90)

0.75 (0.27–1.47)

 26–30 yrs old

0.92 (0.86–0.97)

1.28 (0.70–2.03)

0.85 (0.49–1.30)

 31–35 yrs old

0.99 (0.91–1.07)

0.58 (0.15–1.30)

1.53 (1.02–2.15)

 36–40 yrs old

1.28 (1.10–1.46)

2.05 (0.81–3.84)

1.18 (0.61–1.94)

 41–45 yrs old

1.48 (1.11–1.90)

1.58 (0.15–4.54)

1.35 (0.43–2.80)

 46–70 yrs old

1.02 (0.53–1.69)

1.80 (0.34–4.40)

Father's cancer site

 Head & neck

1.14 (0.95–1.34)

0.39 (0.00–1.54)

 Digestive tract

1.07 (0.98–1.17)

1.09 (0.20–2.66)

1.55 (0.61–2.91)

 Thoracic

1.16 (1.03–1.30)

1.23 (0.00–4.80)

 Breast

1.09 (0.28–2.41)

 Prostate

0.97 (0.88–1.06)

 Reproductive

0.87 (0.67–1.10)

0.84 (0.22–1.87)

1.15 (0.59–1.90)

 Skin

0.82 (0.69–0.96)

1.53 (0.48–3.16)

1.58 (0.81–2.60)

 Brain & eye

0.89 (0.75–1.05)

0.25 (0.00–0.98)

0.75 (0.30–1.41)

 Thyroid

1.26 (1.03–1.52)

0.63 (0.00–2.47)

1.42 (0.61–2.58)

 Bone

0.88 (0.76–1.00)

2.16 (0.85–4.05)

0.82 (0.33–1.55)

 Hematopoietic

0.90 (0.76–1.05)

2.01 (0.91–3.54)

1.20 (0.54–2.10)

 Others

0.98 (0.88–1.09)

0.51 (0.00–2.00)

1.40 (0.56–2.64)

Father's parity status at start of observation period

 Nulliparous

0.99 (0.95–1.02)

1.17 (0.62–1.90)

0.95 (0.68–1.28)

 Parous

1.58 (1.20–2.03)

1.07 (0.63–1.61)

1.54 (1.06–2.10)

Father's age at diagnosis

 0–12

1.25 (0.33–2.78)

 13–18

0.95 (0.38–1.78)

 19+

0.99 (0.96–1.03)

1.11 (0.76–1.54)

1.17 (0.89–1.48)

  1. aChildren born >1 year prior to father’s cancer diagnosis
  2. bChildren born between 1 year before and 1 year after father’s cancer diagnosis
  3. cChildren born >1 year after father’s cancer diagnosis
  4. Bold number units indicate a significant difference in SMRs