Fig. 5
From: Improving gastric cancer preclinical studies using diverse in vitro and in vivo model systems
Identification of genetic alterations of ERBB2 downstream signaling genes between the high- vs. low-expressing groups. a From the ERBB2 downstream genes (including ERBB2 itself), we identified genetic alterations (e.g., copy number variations, mutations) between the two GC patient groups using cBioPortal (cbioportal.org) at its default setting. The y-axis represents the percentage of patients with the altered gene, in terms of copy number variations and mutations. The red bar indicates the high ERBB2-expressing sample group, and the blue bar indicates the low ERBB2-expressing sample group. The three genes (PIK3CA, PTK2, NFKBIE), indicated by numbers showed the most alteration in the high ERBB2-expressing group, compared to the low ERBB2-expressing group. b The genetic alteration profile for the three genes (PIK3CA, PTK2, and NFKBIE) indicated in the numbers above, is shown for the high ERBB2-expressing GC patients