Fig. 4
From: Improving gastric cancer preclinical studies using diverse in vitro and in vivo model systems
Signaling network is common to both ERBB2 high- and low-expressing gastric cancer patients in TCGA. a The network was delineated by our established systems biology algorithm, PATHOME [22]. The network consists of subsets of multiple KEGG pathways, as indicated by the numerals. Nodes represent gene symbols, with the depth of red indicating greater upregulation in the ERBB2 low-expressing patient group. The depth of the blue color indicates upregulation in ERBB2 high-expressing patients group. b KEGG information provided according to the numerals in a. c ERBB2 downstream signaling. We extracted ERBB2 downstream from Fig. 4a, revealing 51 downstream genes (including ERBB2 itself)