Table 1 Characteristics of Studies Investigating Stroke Related to ADT
First author year | Design, LOE | Database source (Duration) | Definition of Stroke (ICD codes) | Types of ADT | Treatments of control | No. of ADT/Control | Age ya(SD) of patients | Follow-up, (ya) | Hazard Ratios(95%CI) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Jespersen et al. [25] 2013 | Cohort, 2a | Danish Cancer Registry (2002–2010) | Ischemic Stroke/TIA (ICD-8 codes 433, 434.09/99, 436.01/436.90, ICD-10 codes DI63.x, DI64.x) | GnRH/AA | non-ADT | 9204 | 20,307 | 71 | 3.3 (1.8 to 5.2) | 1.19(1.06,1.35)c | 1.17 (0.94, 1.50)d | |
Orchiectomy | 2060 | 1.11(0.90,1.36)c | ||||||||||
Hemelrijck et al. [24] 2010 | Cohort, 2a | NPCR of Sweden (1997–2007) | Stroke (ICD-10: 160–164, G45) | GnRH agonist | RP | 9066 | 26,432 | ≤65: 19,153 | 3.8 | 4.4 | 1.21(1.11,1.32)b | 1.16 (1.01, 1.32)d |
AA | 3391 | 4 | 0.88(0.76,1.00)b | |||||||||
GnRH + AA | WW/AS | 11,646 | 19,527 | 66 to 74: 27,737 | 3.3 | 4.7 | 1.25(1.15,1.35)b | |||||
Orchiectomy | 5340 | ≥75: 13,110 | 3.1 | 1.30(1.18,1.44)b | ||||||||
Other types | 1199 | - | - | |||||||||
Alibhai et al. [14] 2009 | Cohort, 2a | ICES (1995–2005) | Stroke (ICD-9-CM codes 430–438) | ADT | non-ADT | 19,079/19,079 | 75 ± 6.3 | 6.47 | 0.88(0.81,0.96)c | |||
Keating et al. [23] 2010 | Cohort, 2a | Veterans Healthcare Administration (2001–2004) | Ischemic Stroke/TIA (ICD-9 codes 433.XX −435.XX) | GnRH agonist | WW/AS | 14,037 | 22,846 | 66.9 ± 8.6 | 2.6 | 1.18(1.02,1.36)c | 1.18 (0.91, 1.51)d | |
AA | 1229 | 0.89(0.46,1.73)c | ||||||||||
GnRH + AA | 1838 | 0.91(0.60,1.39)c | ||||||||||
Orchiectomy | 308 | 1.81(1.15,2.84)c | ||||||||||
Huang et al. [21], 2014 | Cohort, 2a | Queen Mary Hospital, Hong Kong (1998–2011) | Ischemic Stroke (NA) | ADT | non-ADT | 517/228 | 72.2 ± 0.3 | 5.3 | 0.94 (0.35, 2.45)c | |||
Azoulay et al. [13] 2011 | Nested Case–control, 2a | GPRD (1988–2008) | Stroke/TIA (NA) | GnRH agonist | non-ADT | 3274 | 3960 | 72.3 ± 3.9 | 3.9 | 1.18(1.00,1.39)c | 1.34 (1.15, 1.55)d | |
AA | 457 | 1.47(1.08,2.01)c | ||||||||||
GnRH + AA | 481 | 1.26(0.93,1.72)c | ||||||||||
Orchiectomy | 295 | 1.77(1.25,2.51)c | ||||||||||
Other types | 142 | 1.42(0.84,2.39)c | ||||||||||