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Table 9 Mean toxicokinetic parameters at day 1 and 28-day dosing of α-TEA lysine salt

From: GMP-grade α-TEA lysine salt: a 28-Day oral toxicity and toxicokinetic study with a 28-Day recovery period in Beagle dogs

Day Group α-TEA Dose (mg/kg) Sex Tmax (hr) T1/2 (hr) Cmax (ng/mL) AUC0-24 (hr*ng/ml)
1 2 100 Male 24 NC 20200 335000
1 2 100 Female 20 NC 23900 35100
1 3 300 Male 16 NC 41000 718000
1 3 300 Female 18.7 NC 48600 72900
1 4 1500 Male 24 NC 69100 1170000
1 4 1500 Female 16 NC 76900 1240000
28 2 100 Male 6.3 NC 148000 3290000
28 2 100 Female 7 NC 16000 3620000
28 3 300 Male 7.3 NC 211000 4740000
28 3 300 Female 8 NC 212000 4670000
29 4 1500 Male 8 NC 206000 4580000
28 4 1500 Female 10.7 NC 192000 4210000
  1. Blood were collected collected at 1, 2, 4, 8, and 24 h following the first α-TEA administration and 2, 8, 24, 72, and 168 h following the last administration (day 28). The validated method (high performance liquid chromatography with mass spectrometric detection) was used to analyse plasma α-TEA concentration. Cmax, Tmax, T1/2, AUC were determined using WinNonlin Version 6.2 software system