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Table 8 Mean serum chemistry parameters in dogs at the end of the recovery period (Day 57)

From: GMP-grade α-TEA lysine salt: a 28-Day oral toxicity and toxicokinetic study with a 28-Day recovery period in Beagle dogs

   Vehicle 300 mg/kg 1500 mg/kg Unit
   Mean N Mean N Mean N  
Males Alanine transaminase (ALT) 33 2 36.5 2 33 2 U/L
Aspartate transaminase (AST) 31 2 30.5 2 33 2 U/L
Alkaline phosphatase (ALKP) 81.5 2 66 2 95 2 U/L
Lactate deshydrogenase (LDH) 36 2 50 2 45.5 2 U/L
Total bilirubin (TBILI) 0.05 2 0.05 2 0.1 2 mg/dl
Gamma-Glutamyl transferase (GGT) 0 2 1 2 0 2 U/L
Creatine phosphokinase (CK) 119 2 142.5 2 169 2 U/L
Sodium (Na) 147.5 2 146.5 2 148.5 2 mmol/L
Potassium (K) 4.3 2 4.6 2 4.4 2 mmol/L
Chloride (CL) 116 2 115 2 116.5 2 mmol/L
Calcium (CA) 10.65 2 10.45 2 10.55 2 mg/dL
Inorganic phosphorus (PHOS) 5.15 2 5.1 2 5.3 2 mg/dL
Blood urea nitrogen (BUN) 13.5 2 15.5 2 21 2 mg/dL
Creatinine (CREA) 0.65 2 0.6 2 0.7 2 mg/dL
Glucose (GLU) 99 2 99.5 2 96 2 mg/dL
Total protein (TPRO) 5.3 2 5.15 2 5.4 2 g/dL
Albumin (ALB) 3 2 2.9 2 2.95 2 g/dL
Globulin (GLOB) 2.3 2 2.25 2 2.45 2 g/dL
Albumin/Globulin ratio (A/G) 1.314 2 1.289 2 1.219 2 Ratio
Cholesterol (CHOL) 149 2 154 2 163.5 2 mg/dL
Triglycerides (TRIG) 24 2 24 2 41 2 mg/dL
Females Alanine transaminase (ALT) 22.5 2 31 2 27.5 2 U/L
Aspartate transaminase (AST) 33 2 29 2 26.5 2 U/L
Alkaline phosphatase (ALKP) 73 2 63.5 2 50 2 U/L
Lactate deshydrogenase (LDH) 52 2 49.5 2 47 2 U/L
Total bilirubin (TBILI) 0.1 2 0.1 2 0.1 2 mg/dL
Gamma-Glutamyl transferase (GGT) 0 2 0 2 0 0 U/L
Creatine phosphokinase (CK) 154.5 2 146 2 120 2 U/L
Sodium (Na) 146.5 2 146.5 2 147 2 mmol/L
Potassium (K) 4.5 2 4.5 2 4.1 2 mmol/L
Chloride (CL) 115.5 2 115.5 2 116.5 2 mmol/L
Calcium (CA) 10.95 2 10.65 2 10.5 2 mg/dL
Inorganic phosphorus (PHOS) 5.15 2 4.95 2 4.5 2 mg/dL
Blood urea nitrogen (BUN) 15.5 2 13.5 2 14.5 2 mg/dL
Creatinine (CREA) 0.65 2 0.7 2 0.65 2 mg/dL
Glucose (GLU) 103.5 2 101.5 2 100 2 mg/dL
Total protein (TPRO) 5.7 2 5.15 2 5.25 2 g/dL
Albumin (ALB) 3.3 2 3 2 3.1 2 g/dL
Globulin (GLOB) 2.4 2 2.15 2 2.15 2 g/dL
Albumin/Globulin ratio (A/G) 1.377 2 1.395 2 1.444 2 Ratio
Cholesterol (CHOL) 190.5 2 152 2 161 2 mg/dL
Triglycerides (TRIG) 29.5 2 30.5 2 32 2 mg/dL
  1. Male and female dogs received indicated doses of α-TEA lysine salt daily for 28 days. At the end of the recovery period, on day 57, blood was collected from 2 dogs per treatment group and analyzed