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Table 8 Mean serum chemistry parameters in dogs at the end of the recovery period (Day 57)

From: GMP-grade α-TEA lysine salt: a 28-Day oral toxicity and toxicokinetic study with a 28-Day recovery period in Beagle dogs

  

Vehicle

300 mg/kg

1500 mg/kg

Unit

  

Mean

N

Mean

N

Mean

N

 

Males

Alanine transaminase (ALT)

33

2

36.5

2

33

2

U/L

Aspartate transaminase (AST)

31

2

30.5

2

33

2

U/L

Alkaline phosphatase (ALKP)

81.5

2

66

2

95

2

U/L

Lactate deshydrogenase (LDH)

36

2

50

2

45.5

2

U/L

Total bilirubin (TBILI)

0.05

2

0.05

2

0.1

2

mg/dl

Gamma-Glutamyl transferase (GGT)

0

2

1

2

0

2

U/L

Creatine phosphokinase (CK)

119

2

142.5

2

169

2

U/L

Sodium (Na)

147.5

2

146.5

2

148.5

2

mmol/L

Potassium (K)

4.3

2

4.6

2

4.4

2

mmol/L

Chloride (CL)

116

2

115

2

116.5

2

mmol/L

Calcium (CA)

10.65

2

10.45

2

10.55

2

mg/dL

Inorganic phosphorus (PHOS)

5.15

2

5.1

2

5.3

2

mg/dL

Blood urea nitrogen (BUN)

13.5

2

15.5

2

21

2

mg/dL

Creatinine (CREA)

0.65

2

0.6

2

0.7

2

mg/dL

Glucose (GLU)

99

2

99.5

2

96

2

mg/dL

Total protein (TPRO)

5.3

2

5.15

2

5.4

2

g/dL

Albumin (ALB)

3

2

2.9

2

2.95

2

g/dL

Globulin (GLOB)

2.3

2

2.25

2

2.45

2

g/dL

Albumin/Globulin ratio (A/G)

1.314

2

1.289

2

1.219

2

Ratio

Cholesterol (CHOL)

149

2

154

2

163.5

2

mg/dL

Triglycerides (TRIG)

24

2

24

2

41

2

mg/dL

Females

Alanine transaminase (ALT)

22.5

2

31

2

27.5

2

U/L

Aspartate transaminase (AST)

33

2

29

2

26.5

2

U/L

Alkaline phosphatase (ALKP)

73

2

63.5

2

50

2

U/L

Lactate deshydrogenase (LDH)

52

2

49.5

2

47

2

U/L

Total bilirubin (TBILI)

0.1

2

0.1

2

0.1

2

mg/dL

Gamma-Glutamyl transferase (GGT)

0

2

0

2

0

0

U/L

Creatine phosphokinase (CK)

154.5

2

146

2

120

2

U/L

Sodium (Na)

146.5

2

146.5

2

147

2

mmol/L

Potassium (K)

4.5

2

4.5

2

4.1

2

mmol/L

Chloride (CL)

115.5

2

115.5

2

116.5

2

mmol/L

Calcium (CA)

10.95

2

10.65

2

10.5

2

mg/dL

Inorganic phosphorus (PHOS)

5.15

2

4.95

2

4.5

2

mg/dL

Blood urea nitrogen (BUN)

15.5

2

13.5

2

14.5

2

mg/dL

Creatinine (CREA)

0.65

2

0.7

2

0.65

2

mg/dL

Glucose (GLU)

103.5

2

101.5

2

100

2

mg/dL

Total protein (TPRO)

5.7

2

5.15

2

5.25

2

g/dL

Albumin (ALB)

3.3

2

3

2

3.1

2

g/dL

Globulin (GLOB)

2.4

2

2.15

2

2.15

2

g/dL

Albumin/Globulin ratio (A/G)

1.377

2

1.395

2

1.444

2

Ratio

Cholesterol (CHOL)

190.5

2

152

2

161

2

mg/dL

Triglycerides (TRIG)

29.5

2

30.5

2

32

2

mg/dL

  1. Male and female dogs received indicated doses of α-TEA lysine salt daily for 28 days. At the end of the recovery period, on day 57, blood was collected from 2 dogs per treatment group and analyzed