Table 7 Mean serum chemistry parameters 29 days after the start date in male dogs
Vehicle | 100 mg/kg | 300 mg/kg | 1500 mg/kg | Unit | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean | SD | N | Mean | SD | N | Mean | SD | N | Mean | SD | N | |||
Males | Alanine transaminase (ALT) | 33.5 | 9.9 | 4 | 32 | 8.6 | 4 | 37.3 | 6.8 | 4 | 51 | 25.9 | 4 | U/L |
Aspartate transaminase (AST) | 34.8 | 3.2 | 4 | 36.5 | 5.7 | 4 | 46 | 8.8 | 4 | 49.8 | 5.9 | 4 | U/L | |
Alkaline phosphatase (ALKP) | 96 | 24.4 | 4 | 104.3 | 37.1 | 4 | 116 | 71.9 | 4 | 227 | 315.9 | 4 | U/L | |
Lactate deshydrogenase (LDH) | 57.8 | 6.4 | 4 | 61 | 18.7 | 4 | 70 | 21.8 | 4 | 55 | 18.9 | 4 | U/L | |
Total bilirubin (TBILI) | 0.03 | 0.05 | 4 | 0.03 | 0.05 | 4 | 0.03 | 0.05 | 4 | 0 | 0 | 4 | mg/dL | |
Gamma-Glutamyl transferase (GGT) | 0 | 0 | 4 | 0 | 0 | 4 | 0 | 0 | 4 | 0 | 0 | 4 | U/L | |
Creatine phosphokinase (CK) | 246.3 | 79.8 | 4 | 185.3 | 61.2 | 4 | 272.3 | 145.6 | 4 | 133 | 29.1 | 4 | U/L | |
Sodium (Na) | 148.5 | 1.3 | 4 | 148 | 0.8 | 4 | 147.8 | 0.5 | 4 | 148 | 1.4 | 4 | mmol/L | |
Potassium (K) | 4.35 | 0.31 | 4 | 4.5 | 0.26 | 4 | 4.08 | 0.32 | 4 | 4.48 | 0.21 | 4 | mmol/L | |
Chloride (CL) | 115.8 | 1 | 4 | 115 | 0.8 | 4 | 115 | 1.3 | 4 | 118.8 | 0.5 | 4 | mmol/L | |
Calcium (CA) | 10.83 | 0.25 | 4 | 10.88 | 0.33 | 4 | 11.05 | 0.13 | 4 | 10.35 | 0.29 | 4 | mg/dL | |
Inorganic phosphorus (PHOS) | 5.13 | 0.75 | 4 | 5.45 | 0.29 | 4 | 4.68 | 0.26 | 4 | 3.98 | 0.32 | 4 | mg/dL | |
Blood urea nitrogen (BUN) | 18.3 | 2.1 | 4 | 18.8 | 3.3 | 4 | 19.3 | 1.9 | 4 | 24.3 | 1.7 | 4 | mg/dL | |
Creatinine (CREA) | 0.6 | 0.14 | 4 | 0.6 | 0 | 4 | 0.58 | 0.1 | 4 | 0.55 | 0.08 | 4 | mg/dL | |
Glucose (GLU) | 102.5 | 4 | 4 | 96.3 | 9 | 4 | 96.8 | 11.2 | 4 | 80.8 | 8.4 | 4 | mg/dL | |
Total protein (TPRO) | 5.25 | 0.3 | 4 | 5.38 | 0.28 | 4 | 5.38 | 0.24 | 4 | 4.45 | 0.42 | 4 | g/dL | |
Albumin (ALB) | 3.33 | 0.26 | 4 | 3.23 | 0.29 | 4 | 3.18 | 0.21 | 4 | 2.45 | 0.1 | 4 | g/dL | |
Globulin (GLOB) | 1.93 | 0.1 | 4 | 2.15 | 0.06 | 4 | 2.2 | 0.14 | 4 | 2 | 0.34 | 4 | g/dL | |
Albumin/Globulin ratio (A/G) | 1.729 | 0.141 | 4 | 1.502 | 0.152 | 4 | 1.448 | 0.14 | 4 | 1.247 | 0.184 | 4 | Ratio | |
Cholesterol (CHOL) | 168.8 | 35.4 | 4 | 176 | 28 | 4 | 152.3 | 19.4 | 4 | 104.5 | 183.4 | 4 | mg/dL | |
Triglycerides (TRIG) | 34 | 8.1 | 4 | 41.3 | 9.7 | 4 | 33.3 | 5.6 | 4 | 45.5 | 14.3 | 4 | mg/dL | |
Females | Alanine transaminase (ALT) | 27.3 | 5.1 | 4 | 26.3 | 1.9 | 4 | 35.8 | 10.2 | 4 | 45.5 | 20.9 | 4 | U/L |
Aspartate transaminase (AST) | 29 | 4.7 | 4 | 36.3 | 5.3 | 4 | 31.5 | 3.1 | 4 | 45.8 | 19.5 | 4 | U/L | |
Alkaline phosphatase (ALKP) | 98.8 | 12.4 | 4 | 78.8 | 22.5 | 4 | 178 | 131.5 | 4 | 251.3 | 211.2 | 4 | U/L | |
Lactate deshydrogenase (LDH) | 82.3 | 25.8 | 4 | 74 | 19.8 | 4 | 69.5 | 5.9 | 4 | 73 | 19.5 | 4 | U/L | |
Total bilirubin (TBILI) | 0.03 | 0.05 | 4 | 0.05 | 0.06 | 4 | 0.03 | 0.05 | 4 | 0.03 | 0.05 | 4 | mg/dL | |
Gamma-Glutamyl transferase (GGT) | 0 | 0 | 4 | 0.3 | 0.5 | 4 | 0 | 0 | 4 | 0 | 0 | 4 | U/L | |
Creatine phosphokinase (CK) | 162.8 | 54.3 | 4 | 198.8 | 44.1 | 4 | 162.3 | 40.6 | 4 | 147.3 | 47.6 | 4 | U/L | |
Sodium (Na) | 147.8 | 1 | 4 | 148.5 | 1.9 | 4 | 148.5 | 0.6 | 4 | 148.3 | 1 | 4 | mmol/L | |
Potassium (K) | 4.4 | 0.34 | 4 | 4.53 | 0.17 | 4 | 4.38 | 0.31 | 4 | 4.65 | 0.34 | 4 | mmol/L | |
Chloride (CL) | 114.5 | 1.7 | 4 | 115.5 | 1 | 4 | 115.5 | 1 | 4 | 117.8 | 2.8 | 4 | mmol/L | |
Calcium (CA) | 10.7 | 0.35 | 4 | 11.05 | 0.38 | 4 | 11.05 | 0.37 | 4 | 10.25 | 0.84 | 4 | mg/dL | |
Inorganic phosphorus (PHOS) | 5.03 | 0.54 | 4 | 4.25 | 0.9 | 4 | 4.4 | 0.47 | 4 | 4.35 | 0.58 | 4 | mg/dL | |
Blood urea nitrogen (BUN) | 17.5 | 2.4 | 4 | 14.5 | 1.3 | 4 | 18.5 | 1.3 | 4 | 23.5 | 7.9 | 4 | mg/dL | |
Creatinine (CREA) | 0.5 | 0.08 | 4 | 0.58 | 0.1 | 4 | 0.53 | 0.1 | 4 | 0.63 | 0.05 | 4 | mg/dL | |
Glucose (GLU) | 103.3 | 4.8 | 4 | 102.8 | 11.5 | 4 | 108.8 | 7.8 | 4 | 84.8 | 2.1 | 4 | mg/dL | |
Total protein (TPRO) | 5.28 | 0.17 | 4 | 5.35 | 0.31 | 4 | 5.3 | 0.22 | 4 | 4.65 | 0.3 | 4 | g/dL | |
Albumin (ALB) | 3.35 | 0.17 | 4 | 3.38 | 0.25 | 4 | 3.35 | 0.19 | 4 | 2.8 | 0.22 | 4 | g/dL | |
Globulin (GLOB) | 1.93 | 0.1 | 4 | 1.98 | 0.1 | 4 | 1.95 | 0.17 | 4 | 1.85 | 0.13 | 4 | g/dL | |
Albumin/Globulin ration (A/G) | 1.745 | 0.142 | 4 | 1.71 | 0.109 | 4 | 1.729 | 0.191 | 4 | 1.516 | 0.118 | 4 | Ratio | |
Cholesterol (CHOL) | 167.5 | 24.6 | 4 | 179 | 22.4 | 4 | 147.3 | 10.6 | 4 | 98.3 | 13 | 4 | mg/dL | |
Triglycerides (TRIG) | 40 | 9.8 | 4 | 42 | 8.8 | 4 | 43.5 | 5.8 | 4 | 50 | 8.3 | 4 | mg/dL | |