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Table 5 Mean blood cells and coagulation parameters in dogs at the end of the recovery period (Day 57)

From: GMP-grade α-TEA lysine salt: a 28-Day oral toxicity and toxicokinetic study with a 28-Day recovery period in Beagle dogs

   Vehicle 300 mg/kg 1500 mg/kg Unit
   Mean N Mean N Mean N  
Males Erythrocytes        
 Red blood cells 5.975 2 6.13 2 6.115 2 M/ul
 Hemoglobin 14 2 14.2 2 14.15 2 g/L
 Hematocrit 40 2 40.7 2 40.65 2 %
 Mean corpuscular volume 67 2 6.35 2 66.7 2 fL
 Mean corpuscular hemoglobin 23.4 2 23.15 2 23.2 2 pg
 Mean corpuscular hemoglobin concentration 34.9 2 34.85 2 34.8 2 g/dL
 Reticulocytes 34.15 2 78.3 2 59.92 2 109/L
Leukocytes        
 White blood cells 8.705 2 8.025 2 10.37 2 K/uL
 Neutrophils 5.275 2 4.53 2 6.14 2 K/uL
 Lymphocytes 2.7 2 2.645 2 3.055 2 K/uL
 Monocytes 0.34 2 0.225 2 0.385 2 K/uL
 Eosinophils 0.21 2 0.225 2 0.385 2 K/uL
 Basophils 0.125 2 0.125 2 0.125 2 K/uL
Thrombocytes        
 platelets 229 2 290.5 2 310 2 K/uL
 Mean platelet volume 11.7 2 9.65 2 9.55 2 fL
 Protrombin time 7.05 2 7.15 2 7.15 2 Seconds
 Activated partial thromboplastin time 13.05 2 13.75 2 12.65 2 Seconds
 Fibrinogen        mg/dL
Females Erythrocytes        
 Red blood cells 7.41 2 6.775 2 6.455 2 M/ul
 Hemoglobin 17.25 2 15.7 2 15.05 2 g/L
 Hematocrit 49.65 2 44.75 2 43.25 2 %
 Mean corpuscular volume 66.95 2 66 2 66.8 2 fL
 Mean corpuscular volume hemoglobin 23.3 2 23.15 2 23.3 2 pg
 Mean corpuscular hemoglobin concentration 34.8 2 35.1 2 34.85 2 g/dL
 Reticulocytes 69.4 2 68.25 2 52.3 2 109/L
Leukocytes        
 White blood cells 8.79 2 7.2 2 8.01 2 K/uL
 Neutrophils 4.925 2 3.895 2 4.915 2 K/uL
 Lymphocytes 2.87 2 2.785 2 2.475 2 K/uL
 Monocytes 0.34 2 0.215 2 0.275 2 K/uL
 Eosinophils 0445 2 0.16 2 0.2 2 K/uL
 Basophils 0.165 2 0.11 2 0.11 2 K/uL
Thrombocytes        
 platelets 239.5 2 273 2 274.5 2 K/uL
 Mean platelet volume 11.3 2 11.2 2 10 2 fL
 Prothrombin time 6.7 2 7.35 2 6.8 2 Seconds
 Activated partial thromboplastin time 12.6 2 12.3 2 12.7 2 Seconds
 Fibrinogen 291 2 151.5 2 201.5 2 mg/dL
  1. Male and female dogs received indicated doses of α-TEA lysine salt daily for 28 days. After 28 daily treatments, blood was collected from 2 dogs per treatment group and analyzed for blood cells and coagulation parameters