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Table 5 Mean blood cells and coagulation parameters in dogs at the end of the recovery period (Day 57)

From: GMP-grade α-TEA lysine salt: a 28-Day oral toxicity and toxicokinetic study with a 28-Day recovery period in Beagle dogs

  

Vehicle

300 mg/kg

1500 mg/kg

Unit

  

Mean

N

Mean

N

Mean

N

 

Males

Erythrocytes

       

 Red blood cells

5.975

2

6.13

2

6.115

2

M/ul

 Hemoglobin

14

2

14.2

2

14.15

2

g/L

 Hematocrit

40

2

40.7

2

40.65

2

%

 Mean corpuscular volume

67

2

6.35

2

66.7

2

fL

 Mean corpuscular hemoglobin

23.4

2

23.15

2

23.2

2

pg

 Mean corpuscular hemoglobin concentration

34.9

2

34.85

2

34.8

2

g/dL

 Reticulocytes

34.15

2

78.3

2

59.92

2

109/L

Leukocytes

       

 White blood cells

8.705

2

8.025

2

10.37

2

K/uL

 Neutrophils

5.275

2

4.53

2

6.14

2

K/uL

 Lymphocytes

2.7

2

2.645

2

3.055

2

K/uL

 Monocytes

0.34

2

0.225

2

0.385

2

K/uL

 Eosinophils

0.21

2

0.225

2

0.385

2

K/uL

 Basophils

0.125

2

0.125

2

0.125

2

K/uL

Thrombocytes

       

 platelets

229

2

290.5

2

310

2

K/uL

 Mean platelet volume

11.7

2

9.65

2

9.55

2

fL

 Protrombin time

7.05

2

7.15

2

7.15

2

Seconds

 Activated partial thromboplastin time

13.05

2

13.75

2

12.65

2

Seconds

 Fibrinogen

      

mg/dL

Females

Erythrocytes

       

 Red blood cells

7.41

2

6.775

2

6.455

2

M/ul

 Hemoglobin

17.25

2

15.7

2

15.05

2

g/L

 Hematocrit

49.65

2

44.75

2

43.25

2

%

 Mean corpuscular volume

66.95

2

66

2

66.8

2

fL

 Mean corpuscular volume hemoglobin

23.3

2

23.15

2

23.3

2

pg

 Mean corpuscular hemoglobin concentration

34.8

2

35.1

2

34.85

2

g/dL

 Reticulocytes

69.4

2

68.25

2

52.3

2

109/L

Leukocytes

       

 White blood cells

8.79

2

7.2

2

8.01

2

K/uL

 Neutrophils

4.925

2

3.895

2

4.915

2

K/uL

 Lymphocytes

2.87

2

2.785

2

2.475

2

K/uL

 Monocytes

0.34

2

0.215

2

0.275

2

K/uL

 Eosinophils

0445

2

0.16

2

0.2

2

K/uL

 Basophils

0.165

2

0.11

2

0.11

2

K/uL

Thrombocytes

       

 platelets

239.5

2

273

2

274.5

2

K/uL

 Mean platelet volume

11.3

2

11.2

2

10

2

fL

 Prothrombin time

6.7

2

7.35

2

6.8

2

Seconds

 Activated partial thromboplastin time

12.6

2

12.3

2

12.7

2

Seconds

 Fibrinogen

291

2

151.5

2

201.5

2

mg/dL

  1. Male and female dogs received indicated doses of α-TEA lysine salt daily for 28 days. After 28 daily treatments, blood was collected from 2 dogs per treatment group and analyzed for blood cells and coagulation parameters