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Table 3 Mean blood cells and coagulation parameters in dogs 10 days prior to treatment

From: GMP-grade α-TEA lysine salt: a 28-Day oral toxicity and toxicokinetic study with a 28-Day recovery period in Beagle dogs

   Vehicle 100 mg/kg 300 mg/kg 1500 mg/kg Unit
   Mean SD N Mean SD N Mean SD N Mean SD N  
Males Erythrocytes              
 Red blood cells 6.315 0.485 6 6.418 0.316 4 6.523 0.211 6 6.74 0.416 6 M/ul
 Hemoglobin 13.98 1.13 6 13.83 0.71 4 14.43 0.48 6 14.8 1.21 6 g/L
 Hematocrit 43.18 3.51 6 43.08 1.54 4 44 1.5 6 45.23 3.2 6 %
 Mean corpuscular volume 63.38 0.97 6 67.18 1.55 4 67.52 2.46 6 67.1 1.42 6 fL
 Mean corpuscular hemoglobin 22.1 0.3 6 21.58 0.62 4 22.12 0.78 6 21.95 0.76   pg
 Mean corpuscular hemoglobin concentration 32.37 0.18 6 32.13 0.61 4 32.73 0.2 6 32.73 0.56 6 g/dL
 Reticulocytes 24.63 13.54 6 29.25 7.68 4 22.28 5.7 6 21.75 10 6 109/L
Leukocytes              
 White blood cells 7.473 1.869 6 7.373 1.858 4 9.175 2.951 6 7.103 1.64 6 K/uL
 Neutrophils 1.207 1.602 6 3.9 1.37 4 5.428 2.489 6 3.943 1.249 6 K/uL
 Lymphocytes 2.473 0.55 6 2.69 0.506 4 2.638 0.788 6 2.445 0.445 6 K/uL
 Monocytes 0.512 0.275 6 0.54 0.083 4 0.668 0.413 6 0.375 0.121 6 K/uL
 Eosinophils 0.128 0.077 6 0.14 0.022 4 0.282 0.171 6 0.193 0.108 6 K/uL
 Basophils 0.093 0.051 6 0.063 0.021 4 0.09 0.029 6 0.082 0.018 4 K/uL
Thrombocytes              
 Platelets 381.7 39.4 6 330.8 80.1 4 427.8 82.2 6 360 57.4 6 K/uL
 Mean platelet volume 12.38 1.52 6 14.28 2.15 4 12.62 1.17 6 13.53 0.9 6 fL
 Protrombin time 6.63 0.24 6 6.88 0.17 4 6.8 0.3 6 6.85 0.19 6 Seconds
 Activated partial thromboplastin time 13.12 0.82 6 12.9 0.66 4 13.83 0.81 6 13.33 0.83 6 Seconds
 Fibrinogen 270.2 47.3 6 312.5 47.5 4 282 44.6 6 259.8 56.7 6 Mg/dL
Females Erythrocytes              
 Red blood cells 6.562 0.322 6 6.788 0.297 4 6.49 0.417 6 6.59 0.344 6 M/ul
 Hemoglobin 14.62 0.8 6 15.43 0.77 4 14.12 1.52 6 14.7 0.79 6 g/L
 Hematocrit 45.15 2.42 6 46.98 2.33 4 43.78 3.88 6 45.22 2.26 6 %
 Mean corpuscular volume 68.82 2.46 6 69.2 1.83 4 67.4 2.3 6 68.63 1.52 6 fL
 Mean corpuscular volume hemoglobin 22.3 0.58 6 22.75 0.83 4 21.73 1.12 6 22.32 0.61 6 Pg
 Mean corpuscular hemoglobin concentration 32.4 0.41 6 32.85 0.31 4 32.17 0.65 6 32.55 0.21 6 g/dL
 Reticulocytes 32.4 15.63 6 41.9 19.22 4 34.42 14.98 6 25.3 11.84 6 109/L
Leukocytes              
 White blood cells 8.123 1.412 6 8.54 1.517 4 8.418 2.205 6 8.655 1.246 6 K/uL
 Neutrophils 4.873 1.151 6 4.855 1.139 4 4.88 1.404 6 5.457 0.986 6 K/uL
 Lymphocytes 2.482 0.62 6 2.793 0.381 4 2.578 0.459 6 2.482 0.213 6 K/uL
 Monocytes 0.473 0.079 6 0.513 0.131 4 0.505 0.185 6 0.353 0.119 6 K/uL
 Eosinophils 0.15 0.14 6 0.138 0.019 4 0.313 0.324 6 0.197 0.072 6 K/uL
 Basophils 0.093 0.047 6 0.148 0.038 4 0.08 0.029 6 0.102 0.014 6 K/uL
Thrombocytes              
 platelets 358.8 83 6 350.5 81.3 4 319.2 53.1 6 356.7 49.3 6 K/uL
 Mean platelet volume 13.23 2.08 6 13.13 1.27 4 13.43 1.24 6 12.85 1.05 6 fL
 Prothrombin time 6.9 0.32 6 7.03 0.25 4 6.73 0.36 6 6.97 0.34 6 Seconds
 Activated partial thromboplastin time 13.42 0.65 6 13.4 0.41 4 13.37 0.44 6 13.12 0.37 6 Seconds
 Fibrinogen 227 54.8 6 225.8 90.2 4 219.2 42.6 6 205.8 35.3 6 mg/dL
  1. Male and female dogs received indicated doses of α-TEA lysine salt daily for 28 days. Ten days before the treatment start, blood was collected from 6 dogs (0, 300, 1500 mg/kg treatment groups) or 4 dogs (100 mg/kg treatment group) and analyzed for blood cells and coagulation parameters