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Table 3 Mean blood cells and coagulation parameters in dogs 10 days prior to treatment

From: GMP-grade α-TEA lysine salt: a 28-Day oral toxicity and toxicokinetic study with a 28-Day recovery period in Beagle dogs

  

Vehicle

100 mg/kg

300 mg/kg

1500 mg/kg

Unit

  

Mean

SD

N

Mean

SD

N

Mean

SD

N

Mean

SD

N

 

Males

Erythrocytes

             

 Red blood cells

6.315

0.485

6

6.418

0.316

4

6.523

0.211

6

6.74

0.416

6

M/ul

 Hemoglobin

13.98

1.13

6

13.83

0.71

4

14.43

0.48

6

14.8

1.21

6

g/L

 Hematocrit

43.18

3.51

6

43.08

1.54

4

44

1.5

6

45.23

3.2

6

%

 Mean corpuscular volume

63.38

0.97

6

67.18

1.55

4

67.52

2.46

6

67.1

1.42

6

fL

 Mean corpuscular hemoglobin

22.1

0.3

6

21.58

0.62

4

22.12

0.78

6

21.95

0.76

 

pg

 Mean corpuscular hemoglobin concentration

32.37

0.18

6

32.13

0.61

4

32.73

0.2

6

32.73

0.56

6

g/dL

 Reticulocytes

24.63

13.54

6

29.25

7.68

4

22.28

5.7

6

21.75

10

6

109/L

Leukocytes

             

 White blood cells

7.473

1.869

6

7.373

1.858

4

9.175

2.951

6

7.103

1.64

6

K/uL

 Neutrophils

1.207

1.602

6

3.9

1.37

4

5.428

2.489

6

3.943

1.249

6

K/uL

 Lymphocytes

2.473

0.55

6

2.69

0.506

4

2.638

0.788

6

2.445

0.445

6

K/uL

 Monocytes

0.512

0.275

6

0.54

0.083

4

0.668

0.413

6

0.375

0.121

6

K/uL

 Eosinophils

0.128

0.077

6

0.14

0.022

4

0.282

0.171

6

0.193

0.108

6

K/uL

 Basophils

0.093

0.051

6

0.063

0.021

4

0.09

0.029

6

0.082

0.018

4

K/uL

Thrombocytes

             

 Platelets

381.7

39.4

6

330.8

80.1

4

427.8

82.2

6

360

57.4

6

K/uL

 Mean platelet volume

12.38

1.52

6

14.28

2.15

4

12.62

1.17

6

13.53

0.9

6

fL

 Protrombin time

6.63

0.24

6

6.88

0.17

4

6.8

0.3

6

6.85

0.19

6

Seconds

 Activated partial thromboplastin time

13.12

0.82

6

12.9

0.66

4

13.83

0.81

6

13.33

0.83

6

Seconds

 Fibrinogen

270.2

47.3

6

312.5

47.5

4

282

44.6

6

259.8

56.7

6

Mg/dL

Females

Erythrocytes

             

 Red blood cells

6.562

0.322

6

6.788

0.297

4

6.49

0.417

6

6.59

0.344

6

M/ul

 Hemoglobin

14.62

0.8

6

15.43

0.77

4

14.12

1.52

6

14.7

0.79

6

g/L

 Hematocrit

45.15

2.42

6

46.98

2.33

4

43.78

3.88

6

45.22

2.26

6

%

 Mean corpuscular volume

68.82

2.46

6

69.2

1.83

4

67.4

2.3

6

68.63

1.52

6

fL

 Mean corpuscular volume hemoglobin

22.3

0.58

6

22.75

0.83

4

21.73

1.12

6

22.32

0.61

6

Pg

 Mean corpuscular hemoglobin concentration

32.4

0.41

6

32.85

0.31

4

32.17

0.65

6

32.55

0.21

6

g/dL

 Reticulocytes

32.4

15.63

6

41.9

19.22

4

34.42

14.98

6

25.3

11.84

6

109/L

Leukocytes

             

 White blood cells

8.123

1.412

6

8.54

1.517

4

8.418

2.205

6

8.655

1.246

6

K/uL

 Neutrophils

4.873

1.151

6

4.855

1.139

4

4.88

1.404

6

5.457

0.986

6

K/uL

 Lymphocytes

2.482

0.62

6

2.793

0.381

4

2.578

0.459

6

2.482

0.213

6

K/uL

 Monocytes

0.473

0.079

6

0.513

0.131

4

0.505

0.185

6

0.353

0.119

6

K/uL

 Eosinophils

0.15

0.14

6

0.138

0.019

4

0.313

0.324

6

0.197

0.072

6

K/uL

 Basophils

0.093

0.047

6

0.148

0.038

4

0.08

0.029

6

0.102

0.014

6

K/uL

Thrombocytes

             

 platelets

358.8

83

6

350.5

81.3

4

319.2

53.1

6

356.7

49.3

6

K/uL

 Mean platelet volume

13.23

2.08

6

13.13

1.27

4

13.43

1.24

6

12.85

1.05

6

fL

 Prothrombin time

6.9

0.32

6

7.03

0.25

4

6.73

0.36

6

6.97

0.34

6

Seconds

 Activated partial thromboplastin time

13.42

0.65

6

13.4

0.41

4

13.37

0.44

6

13.12

0.37

6

Seconds

 Fibrinogen

227

54.8

6

225.8

90.2

4

219.2

42.6

6

205.8

35.3

6

mg/dL

  1. Male and female dogs received indicated doses of α-TEA lysine salt daily for 28 days. Ten days before the treatment start, blood was collected from 6 dogs (0, 300, 1500 mg/kg treatment groups) or 4 dogs (100 mg/kg treatment group) and analyzed for blood cells and coagulation parameters