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Table 2 Effect of a single dose of α-TEA lysine salt or free acid on serum pharmacokinetics parameters

From: GMP-grade α-TEA lysine salt: a 28-Day oral toxicity and toxicokinetic study with a 28-Day recovery period in Beagle dogs

Test article Dose level (mg/kg) Tmax (hr) T½ (hr) Cmax (ug/mL) AUC0-24 (hr*ug/mL) AUC0-∞ (hr/*ug/mL)
α-TEA Free Acid 100 8 54.6 20.4 1,180 1,670
α-TEA Lysine Acid 200 4 54. 29.4 1,680 2,470
α-TEA Free Acid 200 24 50.2 14.7 1,020 1,400
  1. α-TEA free acid (100 mg/kg) and α-TEA lysine salt (200 mg/kg) were administered by intravenous injection or oral gavage in BALB/c mice. Blood was collected from 3 mice/group at each time point and analyzed for α-TEA levels by HPLC with mass spectrometric detection (LC-MS/MS). The peak plasma concentration of a drug after administration (Cmax), the time required to reach it (Tmax), the time required for the concentration of the drug to reach half of its original value (T1/2), the area under the plasma drug concentration-time curve (AUC) were determined using WinNonlin Version 6.2 software system