Test article | Dose level (mg/kg) | Tmax (hr) | T½ (hr) | Cmax (ug/mL) | AUC0-24 (hr*ug/mL) | AUC0-∞ (hr/*ug/mL) |
|---|
α-TEA Free Acid | 100 | 8 | 54.6 | 20.4 | 1,180 | 1,670 |
α-TEA Lysine Acid | 200 | 4 | 54. | 29.4 | 1,680 | 2,470 |
α-TEA Free Acid | 200 | 24 | 50.2 | 14.7 | 1,020 | 1,400 |
- α-TEA free acid (100 mg/kg) and α-TEA lysine salt (200 mg/kg) were administered by intravenous injection or oral gavage in BALB/c mice. Blood was collected from 3 mice/group at each time point and analyzed for α-TEA levels by HPLC with mass spectrometric detection (LC-MS/MS). The peak plasma concentration of a drug after administration (Cmax), the time required to reach it (Tmax), the time required for the concentration of the drug to reach half of its original value (T1/2), the area under the plasma drug concentration-time curve (AUC) were determined using WinNonlin Version 6.2 software system
