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Table 3 The association between the NLR and the prognosis of urothelial carcinoma

From: Neutrophil-to-lymphocyte ratio is a prognostic marker in bladder cancer patients after radical cystectomy

Study Year Number of patients Cut-off value Prognosis (high vs low NLR) Hazard ratio (low NLR was set as 1)
Bladder
Gondo et al. [28] 2012 189 2.5 not mentioned (OS) 1.946, p==0.0015
Demirtas et al. [2] 2013 201 2.5 no significant differences N/A
Krane et al. [37] 2013 68 2.5 23 vs 36 months (CSS) 2.25
Hermanns et al. [26] 2014 424 3 43 % vs 64 % (OS) 1.67, p < 0.001
Temraz et al. [38] 2014 68 2.87 2.7 vs 6.0 years (OS) 1.88
Mano et al. [33] 2014 107 (NMIBC) 2.41   3.74, p = 0.004
Viers et al. [39] 2014 unknown unknown   1.03, p = 0.01
Kayner et al. [40] 2014 291 2.50 NMIBC vs MIBC p = 0.028
Current study 2014 74 2.38 52.6 vs 51.7 months (OS) 4.84, p = 0.007
Upper urinary tract
Azuma et al. [41] 2013 137 2.5 29.4 % vs 81.3 % (OS) 6.14, p < 0.0001
Dalpiaz et al. [9] 2013 202 2.7 27 vs 44.5 months (OS) 3.073, p < 0.001
  1. NLR: neutrophil-to-lymphocyte ration, NMIBC: non-muscle-invasive bladder cancer, MIBC: muscle-invasive bladder cancer, OS: overall survival, CSS: cancer-specific survival