Neutrophil-to-lymphocyte ratio is a prognostic marker in bladder cancer patients after radical cystectomy

BMC Cancer

Table 3 The association between the NLR and the prognosis of urothelial carcinoma

Study	Year	Number of patients	Cut-off value	Prognosis (high vs low NLR)	Hazard ratio (low NLR was set as 1)
Bladder
Gondo et al. [28]	2012	189	2.5	not mentioned (OS)	1.946, p==0.0015
Demirtas et al. [2]	2013	201	2.5	no significant differences	N/A
Krane et al. [37]	2013	68	2.5	23 vs 36 months (CSS)	2.25
Hermanns et al. [26]	2014	424	3	43 % vs 64 % (OS)	1.67, p < 0.001
Temraz et al. [38]	2014	68	2.87	2.7 vs 6.0 years (OS)	1.88
Mano et al. [33]	2014	107 (NMIBC)	2.41		3.74, p = 0.004
Viers et al. [39]	2014	unknown	unknown		1.03, p = 0.01
Kayner et al. [40]	2014	291	2.50	NMIBC vs MIBC	p = 0.028
Current study	2014	74	2.38	52.6 vs 51.7 months (OS)	4.84, p = 0.007
Upper urinary tract
Azuma et al. [41]	2013	137	2.5	29.4 % vs 81.3 % (OS)	6.14, p < 0.0001
Dalpiaz et al. [9]	2013	202	2.7	27 vs 44.5 months (OS)	3.073, p < 0.001

NLR: neutrophil-to-lymphocyte ration, NMIBC: non-muscle-invasive bladder cancer, MIBC: muscle-invasive bladder cancer, OS: overall survival, CSS: cancer-specific survival

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