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Table 3 Detection of HPV-16 RNA in oral rinse samples of patients with p16-negative and p16-positive tumors

From: A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16INK4a expression in head and neck squamous cell carcinoma patients

   Tumour p16INK4a status   Tumour p16INK4a status
   Positive Negative   Positive Negative
Oral rinse HPV-16 status Positive
(Endpoint PCR)
24 (60.0 %) 0 (0.0 %) Positive
(qPCR)
22 (55.0 %) 0 (0.0 %)
Negative
(Endpoint PCR)
16 (40.0 %) 40 (100.0 %) Negative
(qPCR)
18 (45.0 %) 40 (100.0 %)
  Sensitivity 0.60 (0.43, 0.75), Specificity 1.00 (0.87, 1.00) PPV 1.00 (0.80, 1.00), NPV 0.71 (0.58, 0.83) Youden 0.6 (0.30, 0.75) Sensitivity 0.55 (0.38, 0.71), Specificity 1.00 (0.87, 1.00) PPV 1.00 (0.78, 1.00), NPV 0.69 (0.55, 0.80) Youden 0.55 (0.26, 0.71)