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Table 3 Detection of HPV-16 RNA in oral rinse samples of patients with p16-negative and p16-positive tumors

From: A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16INK4a expression in head and neck squamous cell carcinoma patients

  

Tumour p16INK4a status

 

Tumour p16INK4a status

  

Positive

Negative

 

Positive

Negative

Oral rinse HPV-16 status

Positive

(Endpoint PCR)

24 (60.0 %)

0 (0.0 %)

Positive

(qPCR)

22 (55.0 %)

0 (0.0 %)

Negative

(Endpoint PCR)

16 (40.0 %)

40 (100.0 %)

Negative

(qPCR)

18 (45.0 %)

40 (100.0 %)

 

Sensitivity 0.60 (0.43, 0.75), Specificity 1.00 (0.87, 1.00) PPV 1.00 (0.80, 1.00), NPV 0.71 (0.58, 0.83) Youden 0.6 (0.30, 0.75)

Sensitivity 0.55 (0.38, 0.71), Specificity 1.00 (0.87, 1.00) PPV 1.00 (0.78, 1.00), NPV 0.69 (0.55, 0.80) Youden 0.55 (0.26, 0.71)