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Table 2 Cox regression analyses of the association between critical weight loss and survival in the entire patient cohort and its two subsets

From: Critical weight loss predicts poor prognosis in nasopharyngeal carcinoma

  OS FFS LR-FFS D-FFS
HR (95 % CI) P HR (95 % CI) P HR (95 % CI) P HR (95 % CI) P
Patient cohort (n = 2399)         
 Unadjusted model 1.411 (1.214–1.639) <0.001 1.383 (1.193–1.603) <0.001 1.487 (1.248–1.771) <0.001 0.941 (0.688–1.287) 0.702
 Adjusted model 1.352 (1.160–1.576) <0.001 3.275 (1.101–9.740) 0.033 6.620 (2.990–14.658) <0.001 1.432 (0.149–13.736) 0.755
Subset I (n = 1374)         
Matched/Unadjusted model 1.554 (1.259–1.917) <0.001 1.539 1.251–1.895) <0.001 1.577 (1.241–2.004) <0.001 1.276 (0.763–2.134) 0.352
Matched/Adjusted model 1.515 (1.227–1.871) <0.001 1.504 (1.221–1.852) <0.001 9.395 (2.965–29.765) <0.001 0.846 (0.02–36.683) 0.931
Subset II (n = 110)         
Matched/Unadjusted model 4.857 (1.049–22.483) 0.043 4.857 (1.049–22.483) 0.043 5.143 (0.601–44.027) 0.135 2.037 (0.185–22.470) 0.560
Matched/Adjusted model 4.998 (1.080–23.141) 0.040 4.986 (1.077–23.086) 0.040 5.356 (0.623–46.011) 0.126 1.656 (0.144–19.117) 0.680
  1. Notes: Patient cohort: the entire patients; Subset I: the patient cohort received radiotherapy alone or concurrent chemoradiotherapy after matching. Subset II: The patient cohort received IMRT after matching. Critical weight loss: weight loss ≥4.6 %. Adjusted for age (continuous variable), gender (female vs. male), UICC T stage (T1-2 vs. T3-4), UICC N stage (N0-1 vs. N2-3), treatment group (RT vs. CRT), BMI (continuous variable), smoking status (Never smokers vs. ex-smokers), radiotherapy dose (continuous variable)