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Table 2 Cox regression analyses of the association between critical weight loss and survival in the entire patient cohort and its two subsets

From: Critical weight loss predicts poor prognosis in nasopharyngeal carcinoma

 

OS

FFS

LR-FFS

D-FFS

HR (95 % CI)

P

HR (95 % CI)

P

HR (95 % CI)

P

HR (95 % CI)

P

Patient cohort (n = 2399)

        

 Unadjusted model

1.411 (1.214–1.639)

<0.001

1.383 (1.193–1.603)

<0.001

1.487 (1.248–1.771)

<0.001

0.941 (0.688–1.287)

0.702

 Adjusted model

1.352 (1.160–1.576)

<0.001

3.275 (1.101–9.740)

0.033

6.620 (2.990–14.658)

<0.001

1.432 (0.149–13.736)

0.755

Subset I (n = 1374)

        

Matched/Unadjusted model

1.554 (1.259–1.917)

<0.001

1.539 1.251–1.895)

<0.001

1.577 (1.241–2.004)

<0.001

1.276 (0.763–2.134)

0.352

Matched/Adjusted model

1.515 (1.227–1.871)

<0.001

1.504 (1.221–1.852)

<0.001

9.395 (2.965–29.765)

<0.001

0.846 (0.02–36.683)

0.931

Subset II (n = 110)

        

Matched/Unadjusted model

4.857 (1.049–22.483)

0.043

4.857 (1.049–22.483)

0.043

5.143 (0.601–44.027)

0.135

2.037 (0.185–22.470)

0.560

Matched/Adjusted model

4.998 (1.080–23.141)

0.040

4.986 (1.077–23.086)

0.040

5.356 (0.623–46.011)

0.126

1.656 (0.144–19.117)

0.680

  1. Notes: Patient cohort: the entire patients; Subset I: the patient cohort received radiotherapy alone or concurrent chemoradiotherapy after matching. Subset II: The patient cohort received IMRT after matching. Critical weight loss: weight loss ≥4.6 %. Adjusted for age (continuous variable), gender (female vs. male), UICC T stage (T1-2 vs. T3-4), UICC N stage (N0-1 vs. N2-3), treatment group (RT vs. CRT), BMI (continuous variable), smoking status (Never smokers vs. ex-smokers), radiotherapy dose (continuous variable)