Table 1 Protein targets
From: Dynamic modulation of phosphoprotein expression in ovarian cancer xenograft models
Entrez Gene ID | Gene symbol | Protein (phospho-protein) | Gene name | Function |
|---|---|---|---|---|
1017 | CDK2 | CDK2, pCDK2 | cyclin-dependent kinase 2 | CELL CYCLE |
891 | CCNB1 | CyclinB1 | cyclin B1 | CELL CYCLE |
595 | CCND1 | CyclinD1 | cyclin D1 | CELL CYCLE |
4609 | MYC | Myc | v-myc myelocytomatosis viral oncogene homolog (avian) | CELL CYCLE |
1026 | CDKN1A | P21 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | CELL CYCLE |
1027 | CDKN1B | P27 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | CELL CYCLE |
5925 | RB1 | pRb | retinoblastoma 1 | CELL CYCLE |
672 | BRCA1 | BRCA1, pBRCA1 | breast cancer 1, early onset | DNA DAMAGE REPAIR |
2067 | ERCC1 | ERCC1 | excision repair cross-complementing rodent repair deficiency, complementation group 1 | DNA DAMAGE REPAIR |
4292 | MLH1 | MLH1 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | DNA DAMAGE REPAIR |
4436 | MSH2 | MSH2 | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | DNA DAMAGE REPAIR |
2956 | MSH6 | MSH6 | mutS homolog 6 (E. coli) | DNA DAMAGE REPAIR |
1111 | CHEK1 | pChk1 | CHK1 checkpoint homolog (S. pombe) | DNA DAMAGE REPAIR |
3014 | H2AFX | pH2AX | H2A histone family, member X | DNA DAMAGE REPAIR |
3021 | H3F3B | pHH3 | H3 histone, family 3B (H3.3B) | DNA DAMAGE REPAIR |
5395 | PMS2 | PMS2 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | DNA DAMAGE REPAIR |
7157 | TP53 | pP53 | tumor protein p53 | DNA DAMAGE REPAIR |
8202 | NCOA3 | AIB1 | nuclear receptor coactivator 3 | GROWTH SIGNALING:MAPK signaling |
207 | AKT1 | AKT, pAKT | v-akt murine thymoma viral oncogene homolog 1 | GROWTH SIGNALING:PI3K/AKT signaling |
1499 | CTNNB1 | BCatenin, pBCatenin | catenin (cadherin-associated protein), beta 1, 88Â kDa | GROWTH SIGNALING:Wnt signaling |
1956 | EGFR | EGFR | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | GROWTH SIGNALING:ERBB signaling |
2099 | ESR1 | ER,pER | estrogen receptor 1 | GROWTH SIGNALING:ESR signaling |
5594 | MAPK1 | ERK, pERK | mitogen-activated protein kinase 1 | GROWTH SIGNALING:MAPK signaling |
2064 | ERBB2 | HER2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | GROWTH SIGNALING:ERBB signaling |
2065 | ERBB3 | HER3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | GROWTH SIGNALING:ERBB signaling |
2066 | ERBB4 | HER4 | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) | GROWTH SIGNALING:ERBB signaling |
3486 | IGFBP3 | IGFBP3 | insulin-like growth factor binding protein 3 | GROWTH SIGNALING: IGF signaling |
3488 | IGFBP5 | IGFBP5 | insulin-like growth factor binding protein 5 | GROWTH SIGNALING: IGF signaling |
6194 | RPS6 | S6, pS6 | ribosomal protein S6 | GROWTH SIGNALING:mTOR signaling, hypoxia |
5241 | PGR | PgR | progesterone receptor | GROWTH SIGNALING:PI3K/AKT signaling |
5604 | MAP2K1 | pMEK | mitogen-activated protein kinase kinase 1 | GROWTH SIGNALING:MAPK signaling |
4790 | NFKB1 | pNFkB | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | GROWTH SIGNALING:NFkB signaling |
6774 | STAT3 | pSTAT3 | signal transducer and activator of transcription 3 | GROWTH SIGNALING:Jak/STAT signaling |
5728 | PTEN | PTEN | phosphatase and tensin homolog | GROWTH SIGNALING:PI3K/AKT signaling |
1366 | CLDN7 | Claudin7 | claudin 7 | ETM/INVASION |
999 | CDH1 | Ecadherin | cadherin 1, type 1, E-cadherin (epithelial) | ETM/INVASION |
3091 | HIF1A | HIF1alpha | hypoxia inducible factor 1, alpha subunit | ETM/INVASION |
4233 | MET | MET, pMET | met proto-oncogene | ETM/INVASION |
5054 | SERPINE1 | PAI | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | ETM/INVASION |
6615 | SNAI1 | Snail | snail homolog 1 (Drosophila) | ETM/INVASION |
7431 | VIM | Vimentin | vimentin | ETM/INVASION |