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Table 1 Protein targets

From: Dynamic modulation of phosphoprotein expression in ovarian cancer xenograft models

Entrez Gene ID Gene symbol Protein (phospho-protein) Gene name Function
1017 CDK2 CDK2, pCDK2 cyclin-dependent kinase 2 CELL CYCLE
891 CCNB1 CyclinB1 cyclin B1 CELL CYCLE
595 CCND1 CyclinD1 cyclin D1 CELL CYCLE
4609 MYC Myc v-myc myelocytomatosis viral oncogene homolog (avian) CELL CYCLE
1026 CDKN1A P21 cyclin-dependent kinase inhibitor 1A (p21, Cip1) CELL CYCLE
1027 CDKN1B P27 cyclin-dependent kinase inhibitor 1B (p27, Kip1) CELL CYCLE
5925 RB1 pRb retinoblastoma 1 CELL CYCLE
672 BRCA1 BRCA1, pBRCA1 breast cancer 1, early onset DNA DAMAGE REPAIR
2067 ERCC1 ERCC1 excision repair cross-complementing rodent repair deficiency, complementation group 1 DNA DAMAGE REPAIR
4292 MLH1 MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) DNA DAMAGE REPAIR
4436 MSH2 MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) DNA DAMAGE REPAIR
2956 MSH6 MSH6 mutS homolog 6 (E. coli) DNA DAMAGE REPAIR
1111 CHEK1 pChk1 CHK1 checkpoint homolog (S. pombe) DNA DAMAGE REPAIR
3014 H2AFX pH2AX H2A histone family, member X DNA DAMAGE REPAIR
3021 H3F3B pHH3 H3 histone, family 3B (H3.3B) DNA DAMAGE REPAIR
5395 PMS2 PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) DNA DAMAGE REPAIR
7157 TP53 pP53 tumor protein p53 DNA DAMAGE REPAIR
8202 NCOA3 AIB1 nuclear receptor coactivator 3 GROWTH SIGNALING:MAPK signaling
207 AKT1 AKT, pAKT v-akt murine thymoma viral oncogene homolog 1 GROWTH SIGNALING:PI3K/AKT signaling
1499 CTNNB1 BCatenin, pBCatenin catenin (cadherin-associated protein), beta 1, 88 kDa GROWTH SIGNALING:Wnt signaling
1956 EGFR EGFR epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) GROWTH SIGNALING:ERBB signaling
2099 ESR1 ER,pER estrogen receptor 1 GROWTH SIGNALING:ESR signaling
5594 MAPK1 ERK, pERK mitogen-activated protein kinase 1 GROWTH SIGNALING:MAPK signaling
2064 ERBB2 HER2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) GROWTH SIGNALING:ERBB signaling
2065 ERBB3 HER3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) GROWTH SIGNALING:ERBB signaling
2066 ERBB4 HER4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) GROWTH SIGNALING:ERBB signaling
3486 IGFBP3 IGFBP3 insulin-like growth factor binding protein 3 GROWTH SIGNALING: IGF signaling
3488 IGFBP5 IGFBP5 insulin-like growth factor binding protein 5 GROWTH SIGNALING: IGF signaling
6194 RPS6 S6, pS6 ribosomal protein S6 GROWTH SIGNALING:mTOR signaling, hypoxia
5241 PGR PgR progesterone receptor GROWTH SIGNALING:PI3K/AKT signaling
5604 MAP2K1 pMEK mitogen-activated protein kinase kinase 1 GROWTH SIGNALING:MAPK signaling
4790 NFKB1 pNFkB nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 GROWTH SIGNALING:NFkB signaling
6774 STAT3 pSTAT3 signal transducer and activator of transcription 3 GROWTH SIGNALING:Jak/STAT signaling
5728 PTEN PTEN phosphatase and tensin homolog GROWTH SIGNALING:PI3K/AKT signaling
1366 CLDN7 Claudin7 claudin 7 ETM/INVASION
999 CDH1 Ecadherin cadherin 1, type 1, E-cadherin (epithelial) ETM/INVASION
3091 HIF1A HIF1alpha hypoxia inducible factor 1, alpha subunit ETM/INVASION
4233 MET MET, pMET met proto-oncogene ETM/INVASION
5054 SERPINE1 PAI serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 ETM/INVASION
6615 SNAI1 Snail snail homolog 1 (Drosophila) ETM/INVASION
7431 VIM Vimentin vimentin ETM/INVASION
  1. Details and function of 49 protein form targets (41 proteins) and their pathways tested in the xenograft protein expression experiment. There were 16 phosphorylated proteins, 8 of which were tested for both phosphorylated and unphosphorylated forms