TY - JOUR AU - Afasizheva, Anna AU - Devine, Alexus AU - Tillman, Heather AU - Fung, King Leung AU - Vieira, Wilfred D. AU - Blehm, Benjamin H. AU - Kotobuki, Yorihisa AU - Busby, Ben AU - Chen, Emily I. AU - Tanner, Kandice PY - 2016 DA - 2016/03/05 TI - Mitogen-activated protein kinase signaling causes malignant melanoma cells to differentially alter extracellular matrix biosynthesis to promote cell survival JO - BMC Cancer SP - 186 VL - 16 IS - 1 AB - Intrinsic and acquired resistance to drug therapies remains a challenge for malignant melanoma patients. Intratumoral heterogeneities within the tumor microenvironment contribute additional complexity to the determinants of drug efficacy and acquired resistance. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-016-2211-7 DO - 10.1186/s12885-016-2211-7 ID - Afasizheva2016 ER -