Table 2 SNPs associated with breast cancer risk

APOBEC3B

CC

181 (80.09)

176 (88.00)

1.00

rs8142462

TC

42 (18.58)

24 (12.00)

1.70 (0.99-2.93)

0.0500

TT

3 (1.33)

0 (0.00)

0 (0)

0.9839

Dom

45 (19.91)

24 (12.00)

1.82 (1.07-3.12)

0.0300

Overall

0.1584

APOBEC3A

GG

111 (49.12)

125 (62.50)

1.00

rs17370615

GA

102 (45.13)

66 (33.00)

1.74 (1.16-2.60)

0.0068

AA

13 (5.75)

9 (4.50)

1.63 (0.67-3.95)

0.2826

Dom

115 (50.88)

75 (37.50)

1.73 (1.17-2.54)

0.0050

Overall

0.0217

APOBEC3B

CC

95 (42.0)

69 (34.50)

1.00

rs28401571

CT

93 (41.15)

80 (40.00)

0.84 (0.55-1.30)

0.4412

TT

38 (16.81)

51 (25.50)

0.54 (0.32-0.91)

0.0212

Add

0.75 (0.58-0.97)

0.0300

Overall

0.0682

APOBEC3B

TT

82 (36.28)

93 (46.50)

1.00

rs6001376

CT

106 (46.90)

87 (43.50)

1.38 (0.92-2.08)

0.1226

CC

38 (16.81)

20 (10.00)

2.15 (1.16-4.00)

0.0148

Add

1.44 (1.09-1.91)

0.0100

Overall

0.0390

APOBEC3B

CC

44 (19.47)

49 (24.50)

1.00

rs1065184

CT

128 (56.64)

119 (59.50)

1.20 (0.74-1.93)

0.4587

TT

54 (23.89)

32 (16.00)

1.88 (1.03-3.42)

0.0385

Add

1.36 (1.01-1.84)

0.0400

Overall

0.1000

ATR

GG

78 (34.51)

94(47.00)

1.00

rs2227928

AG

110 (48.67)

87(43.50)

1.52 (1.01-2.30)

0.0448

AA

38 (16.81)

19(9.50)

2.41 (1.29-4.51)

0.0060

AG + AA

148 (65.49)

106(53.00)

1.68 (1.14-2.49)

0.0090

Overall

0.0123

ARID1B

CC

50 (22.12)

63 (31.50)

1.00

rs73013281

CT

126 (55.75)

90 (45.00)

1.76 (1.11-2.79)

0.0154

TT

50 (22.12)

47 (23.50)

1.34 (0.78-2.31)

0.2915

CT + TT

176 (77.88)

137 (68.50)

1.62 (1.05-2.50)

0.0293

Overall

0.0500

MAP3K1

CC

130 (57.52)

137 (68.50)

1.00

rs832583

AC

80 (35.40)

58 (29.00)

1.45 (0.96-2.20)

0.0770

AA

16 (7.08)

5 (2.50)

3.37 (1.20-9.47)

0.0210

AC + CC

96 (42.48)

63 (31.50)

1.61 (1.08-2.39)

0.0197

Overall

0.0236

NCOR1

CC

102 (45.13)

108 (54.00)

1.00

rs178831

CT

103 (45.58)

82 (41.00)

1.33 (0.89-1.98)

0.1589

TT

21 (9.29)

10 (5.00)

2.22 (1.00-4.95)

0.0500

CT + TT

124 (54.87)

92 (46.00)

1.43 (0.97-2.09)

0.0681

Overall

0.0908

RUNX1

AA

153 (67.70)

165 (82.50)

1.00

rs8130963

AG

70 (30.97)

33 (16.50)

2.29 (1.43-3.65)

0.0005

GG

3 (1.33)

2 (1.00)

1.62 (0.27-9.81)

0.6010

AG + GG

73 (32.30)

35 (17.50)

2.25 (1.42-3.56)

0.0005

Overall

0.0024

RUNX1

CC

53 (23.45)

71 (35.50)

1.00

rs17227210

CT

123 (54.42)

92 (46.00)

1.79 (1.15-2.80)

0.0106

TT

50 (22.12)

37 (18.50)

1.81 (1.04-3.15)

0.0359

CT + TT

173 (76.55)

129 (64.50)

1.80 (1.18-2.74)

0.0066

Overall

0.0249

SMAD4

AA

145 (64.16)

157 (78.50)

1.00

rs12456284

AG

72 (31.86)

39 (19.50)

2.00 (1.27-3.14)

0.0026

GG

9 (3.98)

4 (2.00)

2.44 (0.73-8.08)

0.1457

AG + GG

81 (35.84)

43 (21.50)

2.04 (1.32-3.15)

0.0013

Overall

0.0053

TBX3

CC

104 (46.02)

127 (63.50)

1.00

rs8853

CT

106 (46.90)

60 (30.00)

2.16 (1.43-3.25)

0.0002

TT

16 (7.08)

13 (6.50)

1.50 (0.69-3.27)

0.3037

CT + TT

122 (53.98)

73 (36.50)

2.04 (1.38-3.01)

0.0003

Overall

0.0011

TBX3

TT

118 (52.21)

140 (70.00)

1.00

rs1061651

TC

97 (42.92)

50 (25.00)

2.30 (1.51-3.50)

0.0001

CC

11 (4.87)

10 (5.00)

1.31 (0.54-3.18)

0.5579

TC + CC

108 (47.79)

60 (30.00)

2.14 (1.43-3.18)

0.0002

Overall

0.0005

TBX3

GG

89 (39.38)

106 (53.00)

1.00

rs2242442

AG

104 (46.02)

84 (42.00)

1.47 (0.99-2.21)

0.0500

AA

33 (14.60)

10 (5.00)

3.93 (1.84-8.42)

0.0004

AG + AA

137 (60.62)

94 (47.00)

1.74 (1.18-2.55)

0.0050

Overall

0.0012

TTN

AA

131 (57.96)

139(69.50)

1.00

rs12463674

AG

85 (37.61)

53(26.50)

1.70 (1.12-2.58)

0.0127

GG

10 (4.42)

8(4.00)

1.33 (0.51-3.46)

0.5641

AG + GG

95 (42.04)

61(30.50)

1.65 (1.11-2.47)

0.0140

Overall

0.0436

TTN

CC

135 (59.73)

150 (75.00)

1.00

rs12465459

CT

84 (37.17)

46 (23.00)

2.03 (1.32-3.11)

0.0012

TT

7 (3.10)

4 (2.00)

1.94 (0.56-6.79)

0.2972

CT + TT

91 (40.27)

50 (25.00)

2.02 (1.33-3.07)

0.0009

Overall

0.0041