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Table 2 SNPs associated with breast cancer risk

From: Analysis of functional germline variants in APOBEC3 and driver genes on breast cancer risk in Moroccan study population

Breast cancer risk
Gene/SNP Genotype Cases (%) Controls (%) OR (95 % CI) P-value
APOBEC3B CC 181 (80.09) 176 (88.00) 1.00  
rs8142462 TC 42 (18.58) 24 (12.00) 1.70 (0.99-2.93) 0.0500
TT 3 (1.33) 0 (0.00) 0 (0) 0.9839
Dom 45 (19.91) 24 (12.00) 1.82 (1.07-3.12) 0.0300
Overall     0.1584
APOBEC3A GG 111 (49.12) 125 (62.50) 1.00  
rs17370615 GA 102 (45.13) 66 (33.00) 1.74 (1.16-2.60) 0.0068
AA 13 (5.75) 9 (4.50) 1.63 (0.67-3.95) 0.2826
Dom 115 (50.88) 75 (37.50) 1.73 (1.17-2.54) 0.0050
Overall     0.0217
APOBEC3B CC 95 (42.0) 69 (34.50) 1.00  
rs28401571 CT 93 (41.15) 80 (40.00) 0.84 (0.55-1.30) 0.4412
  TT 38 (16.81) 51 (25.50) 0.54 (0.32-0.91) 0.0212
  Add    0.75 (0.58-0.97) 0.0300
  Overall     0.0682
APOBEC3B TT 82 (36.28) 93 (46.50) 1.00  
rs6001376 CT 106 (46.90) 87 (43.50) 1.38 (0.92-2.08) 0.1226
  CC 38 (16.81) 20 (10.00) 2.15 (1.16-4.00) 0.0148
  Add    1.44 (1.09-1.91) 0.0100
  Overall     0.0390
APOBEC3B CC 44 (19.47) 49 (24.50) 1.00  
rs1065184 CT 128 (56.64) 119 (59.50) 1.20 (0.74-1.93) 0.4587
  TT 54 (23.89) 32 (16.00) 1.88 (1.03-3.42) 0.0385
  Add    1.36 (1.01-1.84) 0.0400
  Overall     0.1000
ATR GG 78 (34.51) 94(47.00) 1.00  
rs2227928 AG 110 (48.67) 87(43.50) 1.52 (1.01-2.30) 0.0448
  AA 38 (16.81) 19(9.50) 2.41 (1.29-4.51) 0.0060
  AG + AA 148 (65.49) 106(53.00) 1.68 (1.14-2.49) 0.0090
  Overall     0.0123
ARID1B CC 50 (22.12) 63 (31.50) 1.00  
rs73013281 CT 126 (55.75) 90 (45.00) 1.76 (1.11-2.79) 0.0154
  TT 50 (22.12) 47 (23.50) 1.34 (0.78-2.31) 0.2915
  CT + TT 176 (77.88) 137 (68.50) 1.62 (1.05-2.50) 0.0293
  Overall     0.0500
MAP3K1 CC 130 (57.52) 137 (68.50) 1.00  
rs832583 AC 80 (35.40) 58 (29.00) 1.45 (0.96-2.20) 0.0770
  AA 16 (7.08) 5 (2.50) 3.37 (1.20-9.47) 0.0210
  AC + CC 96 (42.48) 63 (31.50) 1.61 (1.08-2.39) 0.0197
  Overall     0.0236
NCOR1 CC 102 (45.13) 108 (54.00) 1.00  
rs178831 CT 103 (45.58) 82 (41.00) 1.33 (0.89-1.98) 0.1589
  TT 21 (9.29) 10 (5.00) 2.22 (1.00-4.95) 0.0500
  CT + TT 124 (54.87) 92 (46.00) 1.43 (0.97-2.09) 0.0681
  Overall     0.0908
RUNX1 AA 153 (67.70) 165 (82.50) 1.00  
rs8130963 AG 70 (30.97) 33 (16.50) 2.29 (1.43-3.65) 0.0005
  GG 3 (1.33) 2 (1.00) 1.62 (0.27-9.81) 0.6010
  AG + GG 73 (32.30) 35 (17.50) 2.25 (1.42-3.56) 0.0005
  Overall     0.0024
RUNX1 CC 53 (23.45) 71 (35.50) 1.00  
rs17227210 CT 123 (54.42) 92 (46.00) 1.79 (1.15-2.80) 0.0106
  TT 50 (22.12) 37 (18.50) 1.81 (1.04-3.15) 0.0359
  CT + TT 173 (76.55) 129 (64.50) 1.80 (1.18-2.74) 0.0066
  Overall     0.0249
SMAD4 AA 145 (64.16) 157 (78.50) 1.00  
rs12456284 AG 72 (31.86) 39 (19.50) 2.00 (1.27-3.14) 0.0026
  GG 9 (3.98) 4 (2.00) 2.44 (0.73-8.08) 0.1457
  AG + GG 81 (35.84) 43 (21.50) 2.04 (1.32-3.15) 0.0013
  Overall     0.0053
TBX3 CC 104 (46.02) 127 (63.50) 1.00  
rs8853 CT 106 (46.90) 60 (30.00) 2.16 (1.43-3.25) 0.0002
  TT 16 (7.08) 13 (6.50) 1.50 (0.69-3.27) 0.3037
  CT + TT 122 (53.98) 73 (36.50) 2.04 (1.38-3.01) 0.0003
  Overall     0.0011
TBX3 TT 118 (52.21) 140 (70.00) 1.00  
rs1061651 TC 97 (42.92) 50 (25.00) 2.30 (1.51-3.50) 0.0001
  CC 11 (4.87) 10 (5.00) 1.31 (0.54-3.18) 0.5579
  TC + CC 108 (47.79) 60 (30.00) 2.14 (1.43-3.18) 0.0002
  Overall     0.0005
TBX3 GG 89 (39.38) 106 (53.00) 1.00  
rs2242442 AG 104 (46.02) 84 (42.00) 1.47 (0.99-2.21) 0.0500
  AA 33 (14.60) 10 (5.00) 3.93 (1.84-8.42) 0.0004
  AG + AA 137 (60.62) 94 (47.00) 1.74 (1.18-2.55) 0.0050
  Overall     0.0012
TTN AA 131 (57.96) 139(69.50) 1.00  
rs12463674 AG 85 (37.61) 53(26.50) 1.70 (1.12-2.58) 0.0127
  GG 10 (4.42) 8(4.00) 1.33 (0.51-3.46) 0.5641
  AG + GG 95 (42.04) 61(30.50) 1.65 (1.11-2.47) 0.0140
  Overall     0.0436
TTN CC 135 (59.73) 150 (75.00) 1.00  
rs12465459 CT 84 (37.17) 46 (23.00) 2.03 (1.32-3.11) 0.0012
  TT 7 (3.10) 4 (2.00) 1.94 (0.56-6.79) 0.2972
  CT + TT 91 (40.27) 50 (25.00) 2.02 (1.33-3.07) 0.0009
  Overall     0.0041
  1. OR odds ratio, CI confidence interval, SNP single nucleotide polymorphism