Fig. 2

Heterogeneous expression of ER, PR, and HER2 receptors and increased proliferation. a Representative tissue samples from cancer and not cancer tissues that were stained for HER2, ER, and PR receptor expression. Examples of tissue that stained positively and negatively for the receptors are included. b Representative cancer and not cancer samples stained for the Ki67 proliferation marker. c Data plot analysis of Ki67 positive cells in ER+ vs. ER- tissue samples. Ki67 staining is significantly different between tissues from not cancer, ER+, and ER- breast samples (P < 0.0001, ANOVA) in ER- tissue samples, indicating high grade and an increase in cellular proliferation. The following combinations were significantly different by one-sided t-test: P = 2.834e-05 (ER+ vs. not cancer), 4.576e-06 (ER- vs. not cancer), and P = 0.0009 (ER- vs. ER+). The bar represents the median of all samples in the indicated cohort and includes any unstained samples