Fig. 5
From: At least two well-spaced samples are needed to genotype a solid tumor
Hypothetical diagram illustrating how additional samples (microscopic sections, dotted boxes) can determine when two bulk samples (dotted circles) miss a major tumor tree branch. A public mutation (yellow circle) is present in nearly all the small regions but a private mutation (and 16 others) is missing from the left section of Cancer A. This finding suggests that the left tumor branch (green) was not sampled by the two initial bulk specimens