Fig. 1
From: At least two well-spaced samples are needed to genotype a solid tumor
Colorectal tumors have glandular architectures (Cancer N is illustrated). Public and private mutations can be organized by ancestry, with private mutations acquired during growth. Depending on cell mobility, private mutations may segregate during growth into well defined “left” versus “right” patches, or more complex variegated patches. Importantly, a private mutation “clonal” in one bulk specimen (dotted circle) will usually be less frequent or absent in a sample taken from the opposite side