Table 4 Treatment-related toxicity profiles
| Â | Afatinib | Erlotinib | p-value | |||
|---|---|---|---|---|---|---|
|  | All grades (%) | ≥Grade 3 (%) | All grades (%) | ≥Grade 3 (%) | All grades | ≥Grade 3 |
Rash | 15 (60.0) | 0 (0.0) | 19 (67.9) | 5 (17.9) | 0.04 | 0.03 |
Diarrhea | 15 (60.0) | 7 (28.0) | 3 (10.7) | 1 (3.6) | 0.002 | 0.01 |
Mucositis | 1 (4.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0.29 | NA |
Paronychia | 2 (8.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0.31 | NA |
Impaired liver function | 6 (24.0) | 0 (0.0) | 1 (3.6) | 0 (0.0) | 0.02 | NA |
Hypokalemia | 2 (8.0) | 2 (8.0) | 0 (0.0) | 0 (0.0) | 0.13 | 0.13 |