Fig. 4
From: Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression
Outcomes of patients with neuroblastoma based on MEK1 and NF1 gene expression. The NCI Oncogenomics gene expression databases were evaluated for outcomes of patients with neuroblastoma and Kaplan-Meier survival curves were generated. a Estimated overall survival for patients who have tumors with high NF1 gene expression (n = 177; gray) and low NF1 gene expression (n = 176; black) (log-rank test; p = 1.88e-11). b Estimated overall survival for patients with stage 4 neuroblastoma who have high (n = 35; black) and low (n = 90; dashed black) NF1 gene expression and for patients with tumors of all other stages with high (n = 142; gray) and low (n = 86; dashed gray) NF1 gene expression. c Estimated overall survival for patients who have tumors with high MEK1 gene expression (n = 154; gray) and low MEK1 gene expression (n = 153; black) (log-rank test; p = 0.44). d Estimated overall survival for patients with stage 4 neuroblastoma who have high (n = 44; black) and low (n = 54; dashed black) MEK1 gene expression and for patients with tumors of all other stages with high (n = 110; gray) and low (n = 99; dashed gray) MEK1 gene expression