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Fig. 8 | BMC Cancer

Fig. 8

From: RNA disruption is associated with response to multiple classes of chemotherapy drugs in tumor cell lines

Fig. 8

Caspase-3 activation is associated with RNA disruption after docetaxel treatment in A2780 cells. A2780 cells were treated with 0.2 μM docetaxel (DXL) for 24, 48 or 72 h. a Caspase-3 activity, assayed using a DEVD substrate, in lysates from A2780 cells. b Effect of a caspase-3 inhibitor on caspase-3 activation in lysates from docetaxel treated A2780 cells. c Gel image of RNA disruption in A2780 cells treated with docetaxel, in the presence (+) or absence (−) of caspase-3 inhibitor (Q-DEVD-Oph). d RDI analysis of RNA from A2780 cells treated with docetaxel for 72 h, with and without the caspase-3 inhibitor

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