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Table 1 Affymetrix microarray data of genes downregulated by NFI-C2 and upregulated by FoxF1

From: Forkhead Box F1 promotes breast cancer cell migration by upregulating lysyl oxidase and suppressing Smad2/3 signaling

Gene description

Gene symbol

Cancer association

Reference

ATP-binding cassette, sub-family G (WHITE), member 2

Abcg2/Bcrp

Multi-drug resistance

[41, 42]

Coagulation factor II (thrombin) receptor

F2r/Par1

Migration, invasion

[43]

Epithelial mitogen

Epgn

Proliferation, migration

[44, 45]

Fibronectin 1

Fn1

EMT

[46, 47]

GLI pathogenesis-related 2

Glipr2

EMT

[48]

Latent transforming growth factor beta binding protein 1

Ltbp1

EMT, invasion

[49, 50]

Lysyl oxidase

Lox

Migration, invasion

[17, 20]

Neurophilin 1

Nrp1

Migration, invasion, angiogenesis

[51, 52]

Platelet-derived growth factor, C polypeptid

Pdgfc

Angiogenesis, invasion

[53, 54]

Protease, serine, 23

Prss23

Proliferation

[55]

Rho GTPase activating protein 29

Arhgap29

Migration

[56]

Single stranded DNA binding protein 4

Ssbp4

Genomic stability

[57]

Thrombospondin

Thbs1

Invasion

[58, 59]

Transforming growth factor, beta 2

Tgfb2

EMT, invasion

[60]

WAS/WASL interacting protein family, member 1

Wipf1

Migration, invasion

[61, 62]

Vestigial like 3 (Drosophila)

Vgll3

Proliferation, migration

[63]

Vimentin

Vim

EMT

[64]

  1. Affymetrix microarrays were used to compare the transcriptome of HC11 wild type cells to that of cells overexpressing NFI-C2 or FoxF1. Associating this array with a previous array where the transcriptome of MDA-MB 436 cells overexpressing NFI-C2 or vector control, resulted in 17 genes downregulated by NFI-C2 in both arrays and upregulated by FoxF1 in the HC11 array
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BMC Cancer

ISSN: 1471-2407

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