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Table 1 Affymetrix microarray data of genes downregulated by NFI-C2 and upregulated by FoxF1

From: Forkhead Box F1 promotes breast cancer cell migration by upregulating lysyl oxidase and suppressing Smad2/3 signaling

Gene descriptionGene symbolCancer associationReference
ATP-binding cassette, sub-family G (WHITE), member 2Abcg2/BcrpMulti-drug resistance[41, 42]
Coagulation factor II (thrombin) receptorF2r/Par1Migration, invasion[43]
Epithelial mitogenEpgnProliferation, migration[44, 45]
Fibronectin 1Fn1EMT[46, 47]
GLI pathogenesis-related 2Glipr2EMT[48]
Latent transforming growth factor beta binding protein 1Ltbp1EMT, invasion[49, 50]
Lysyl oxidaseLoxMigration, invasion[17, 20]
Neurophilin 1Nrp1Migration, invasion, angiogenesis[51, 52]
Platelet-derived growth factor, C polypeptidPdgfcAngiogenesis, invasion[53, 54]
Protease, serine, 23Prss23Proliferation[55]
Rho GTPase activating protein 29Arhgap29Migration[56]
Single stranded DNA binding protein 4Ssbp4Genomic stability[57]
ThrombospondinThbs1Invasion[58, 59]
Transforming growth factor, beta 2Tgfb2EMT, invasion[60]
WAS/WASL interacting protein family, member 1Wipf1Migration, invasion[61, 62]
Vestigial like 3 (Drosophila)Vgll3Proliferation, migration[63]
  1. Affymetrix microarrays were used to compare the transcriptome of HC11 wild type cells to that of cells overexpressing NFI-C2 or FoxF1. Associating this array with a previous array where the transcriptome of MDA-MB 436 cells overexpressing NFI-C2 or vector control, resulted in 17 genes downregulated by NFI-C2 in both arrays and upregulated by FoxF1 in the HC11 array