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Table 1 Affymetrix microarray data of genes downregulated by NFI-C2 and upregulated by FoxF1

From: Forkhead Box F1 promotes breast cancer cell migration by upregulating lysyl oxidase and suppressing Smad2/3 signaling

Gene description Gene symbol Cancer association Reference
ATP-binding cassette, sub-family G (WHITE), member 2 Abcg2/Bcrp Multi-drug resistance [41, 42]
Coagulation factor II (thrombin) receptor F2r/Par1 Migration, invasion [43]
Epithelial mitogen Epgn Proliferation, migration [44, 45]
Fibronectin 1 Fn1 EMT [46, 47]
GLI pathogenesis-related 2 Glipr2 EMT [48]
Latent transforming growth factor beta binding protein 1 Ltbp1 EMT, invasion [49, 50]
Lysyl oxidase Lox Migration, invasion [17, 20]
Neurophilin 1 Nrp1 Migration, invasion, angiogenesis [51, 52]
Platelet-derived growth factor, C polypeptid Pdgfc Angiogenesis, invasion [53, 54]
Protease, serine, 23 Prss23 Proliferation [55]
Rho GTPase activating protein 29 Arhgap29 Migration [56]
Single stranded DNA binding protein 4 Ssbp4 Genomic stability [57]
Thrombospondin Thbs1 Invasion [58, 59]
Transforming growth factor, beta 2 Tgfb2 EMT, invasion [60]
WAS/WASL interacting protein family, member 1 Wipf1 Migration, invasion [61, 62]
Vestigial like 3 (Drosophila) Vgll3 Proliferation, migration [63]
Vimentin Vim EMT [64]
  1. Affymetrix microarrays were used to compare the transcriptome of HC11 wild type cells to that of cells overexpressing NFI-C2 or FoxF1. Associating this array with a previous array where the transcriptome of MDA-MB 436 cells overexpressing NFI-C2 or vector control, resulted in 17 genes downregulated by NFI-C2 in both arrays and upregulated by FoxF1 in the HC11 array