Table 4 Ampullary cancer cell lines reported in the literature
Cell line | Primary tumor | Cell line derived from | Histopathology/differentiation | TNM stage | Kras status | Further characterization | Patient follow-up | Reference |
|---|---|---|---|---|---|---|---|---|
Cell lines successfully grown in standard culture medium | ||||||||
MDA-AMP7 | AMPAC | Peritoneal metastasis | Not reported | rpM1 | Not reported | Aneuploidy and structural chromosomal mutations | Peritoneal metastases occurred 9Â months after resection of primary tumor | Frazier et al. (Frazier et al. 1992) |
AVC1 | AMPAC | Primary tumor | Moderately differentiated, arising from villous ampullary adenoma | pT1N0 cM0 | Mutated | Tumorigenic in mice, moderate Gemcitabine sensitivity | Perioperative death | Sorio et al. (Sorio et al. 2004) |
RCB1280 | AMPAC | Liver metastasis | not reported | not reported | Not reported | structural chromosomal mutations | Not reported | RCB |
SNU478 | AMPAC | Primary tumor | poorly differentiated with signet ring cell features | pN0 (0/5) | Wild type | E-Cadherin wild type but methylated | Not reported | Ku et al. (Ku et al. 2002) |
SNU869 | AMPAC | Primary tumor | well differentiated with focal papillary differentiation | pN1 (5/10) | Wild type | E-Cadherin wild type and expressed | Not reported | Ku et al. (Ku et al. 2002) |
Other cell lines reported | ||||||||
UKEAC-99 | AMPAC | Primary tumor | cell line discarded (personal communication with authors) | Peiper et al. (Peiper et al. 2003) | ||||
RCB1281 | AMPAC | Peritoneal metastasis | cell line derived from same patient as RCB1280 | RCB | ||||
RCB1282 | AMPAC | Lymph node metastasus | RCB | |||||