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Table 3 Tumor biologic factors correlating with the intestinal subtype

From: Characterization of various cell lines from different ampullary cancer subtypes and cancer associated fibroblast-mediated responses

Parameter

Subtype

Correlation with INT

INT

PB

POOR

CC

p

CK7 %

70 (0–100)

90 (5–100)

40 (0–90)

-0.24

0.148

CK20 %

90 (0–100)

5 (0–100)

2.5 (0–10)

0.47

0.003

CDX2 %

90 (20–100)

10 (0–80)

45 (0–100)

0.69

0.000

ZEB1 %

0 (0–2)

0 (0–16)

2 (0–3)

-0.32

0.046

VIM %

0 (0–10)

0 (0–10)

0 (0–0)

0.02

0.914

ECad %

100 (50–100)

100 (75–100)

75 (50–100)

0.03

0.869

Budding

8 (0–35)

15 (2–46)

43 (6–66)

-0.46

0.003

CAF

1 (0–2)

2 (0–2)

0.5 (0–1)

-0.34

0.035

  1. CC and p values derived from two-sided Spearman rank correlation. % expression in percentage of tumor cells, Tumor budding measured as number of tumor buds per HPF (high power field)
  2. Abbreviations: INT intestinal, PB pancreatobiliary, POOR poorly differentiated, CC correlation coefficient, KRT cytokeratin staining, CDX2 caudal type homeobox 2, ZEB1 zinc finger and homeobox 1, ECad E-Cadherin, CAF cancer associated fibroblast activation