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Fig. 2 | BMC Cancer

Fig. 2

From: The anti-oxidative transcription factor Nuclear factor E2 related factor-2 (Nrf2) counteracts TGF-β1 mediated growth inhibition of pancreatic ductal epithelial cells -Nrf2 as determinant of pro-tumorigenic functions of TGF-β1

Fig. 2

Different Nrf2 expression in benign, premalignant and malignant pancreatic ductal epithelial cells. H6c7-pBp, H6c7-kras and Colo357 cells were either left untreated or were treated with 10 ng/ml TGF-β1 for 48 h. Representative immunocytochemical stainings of (a) total (t)-Nrf2 and (b) phospho (p)-Nrf2. Magnification x 280 (magnification of images in frames x 540). c Representative western blots showing t-Nrf2 and p-Nrf2 expression in nuclear extracts of H6c7-pBp, H6c7-kras and Colo357 cells either left untreated or treated with 10 ng/ml TGF-β1 for 48 h. Lamin-A, tubulin and Hsp90 were detected as loading control for nuclear, cytosolic and total cell extracts, respectively

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