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Fig. 7 | BMC Cancer

Fig. 7

From: Targeting Rad50 sensitizes human nasopharyngeal carcinoma cells to radiotherapy

Fig. 7

Effect of Ad-RAD50 infection on radiosensitivity of NPC xenografts in mice with IR treatment. a A photograph of a representative xenograft in each group when the mice were sacrificed 14 days after IR. b The tumor growth curve of CNE1 with different treatments. It was shown that IR combined with Ad-RAD50 could inhibit the tumor growth, in contrast to the IR alone. c Mean internally measured tumor volume ± SEM immediately at the time of IR treatment on day 1 and animal sacrificed on day 14. d Mean internally measured change in tumor volume ± SEM in each group. e The weights of tumors from xenografts on day 14 (Mean ± SEM). Ad-RAD50 infection combined with IR significantly decreased tumor weight compared with IR alone or IR combined with Ad-EGFP. f Tumor nodules were subjected to TUNEL assays. g The quantitative analysis of TUNEL assay. Ad-RAD50 infection combined with IR significantly increased the number of apoptotic cells, when compared with IR alone or IR combined with Ad-EGFP. Scale bar: 50 μm; n = 3; Values are depicted as the Mean ± SEM; *P <0.05 and **P < 0.01

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