Fig. 4
From: Targeting Rad50 sensitizes human nasopharyngeal carcinoma cells to radiotherapy
Infection of Ad-Rad50 downregulated the MRN proteins in NPC cells. a and b are the MRN complex proteins in CNE1 infection with Ad-RAD50 combing with 4Gy IR after 24 h; c and d are the corresponding results in 5–8 F cells. Downregulation of wild-type Mre11, Rad50, and Nbs1 proteins was observed in CNE1 cells or 5–8 F cells treated with Ad-RAD50 infection compared to uninfected and Ad-EGFP infected controls, combing with IR or not (the mean optical density of the Western blot bands ± SEM is shown, * P < 0.05, ** P < 0.01)