Table 1 Pathway analysis for genes significantly modulated by the combination compared to individual agents alone
From: IκBα mediates prostate cancer cell death induced by combinatorial targeting of the androgen receptor
Ingenuity pathway analysis | DAVID (KEGG) pathway analysis | ||||
|---|---|---|---|---|---|
Pathway ID | Genes involved | p-value | Pathway ID | Genes involved | p-value |
Molecular Mechanisms of Cancer | FYN, PMAIP1, NFKBIA, GNA15, RHOU, PLCB1 | 8.91 × 10−7 | Pathways in cancer | IGF1R, LAMA1, LAMA3, KLK3, NKX3-1, NFKBIA, ZBTB16, PIAS1, MMP1 | 1.01 × 10−8 |
Inositol Phosphate Metabolism | SYNJ1, SGK1, PLCB1, MAK | 2.75 × 10−6 | Focal adhesion | IGF1R, LAMA1, LAMA3, FYN, THBS1, VCL | 2.66 × 10−6 |
p53 Signaling | PMAIP1, TP53INP1, THBS1, SNAI2, TNFRSF10B | 3.16 × 10−6 | Jak-STAT signaling pathway | SOCS2, LIFR, PIAS1, IL6R | 2.48 × 10−4 |
Prostate Cancer Signaling | NFKBIA, NKX3-1, KLK3 | 8.13 × 10−5 | Small cell lung cancer | LAMA1, LAMA3, NFKBIA, PIAS1 | 2.84 × 10−4 |
Aldosterone Signaling in Epithelial Cells | SGK1, PLCB1, DNAJB14 | 2.88 × 10−4 | Prostate cancer | IGF1R, KLK3, NKX3-1, NFKBIA | 3.02 × 10−4 |
Glioma Signaling | IGF1R | 3.63 × 10−4 | Adherens junction | IGF1R, FYN, SNAI2, VCL | 3.22 × 10−4 |
Biosynthesis of Steroids | HMGCR | 5.25 × 10−4 | Axon guidance | NRP1, FYN, NTNG1, EFNA5 | 4.08 × 10−4 |
NRF2-mediated Oxidative Stress Response | GSTM2, MAF, DNAJB14, ABCC4 | 0.0010 | ECM-receptor interaction | LAMA1, LAMA3, THBS1 | 0.0018 |
Xenobiotic Metabolism Signaling | GSTM2, MAF, CYP3A5 | 0.0013 | Long-term depression | IGF1R, GUCY1A3, PLCB1 | 0.0029 |
TWEAK Signaling | NFKBIA | 0.0016 | Adipocytokine signaling pathway | NFKBIA, ACSL3, CAMKK2 | 0.0038 |
TNFR1 Signaling | NFKBIA | 0.0018 | Gap junction | TUBB, GUCY1A3, PLCB1 | 0.0047 |
TNFR2 Signaling | NFKBIA | 0.0023 | p53 signaling pathway | TNFRSF10B, PMAIP1, THBS1 | 0.0064 |
Role of CHK Proteins in Cell Cycle Checkpoint Control | HUS1 | 0.0026 | T cell receptor signaling pathway | CD8B, FYN, NFKBIA | 0.0073 |
B Cell Receptor Signaling | NFKBIA | 0.0037 | Purine metabolism | POLE2, GUCY1A3, PDE9A | 0.0095 |
Prolactin Signaling | FYN, SOCS2 | 0.0038 | Cytokine-cytokine receptor interaction | TNFRSF10B, LIFR, IL6R | 0.0103 |
PI3K/AKT Signaling | NFKBIA | 0.0060 | Hematopoietic cell lineage | CD8B, IL6R | 0.0355 |
Insulin Receptor Signaling | FYN, SGK1 | 0.0065 | ABC transporters | ABCC4, ABCG1 | 0.0462 |
Death Receptor Signaling | NFKBIA, TNFRSF10B | 0.0083 | Drug metabolism | CYP3A5, NAT1 | 0.0462 |