Fig. 2
From: IκBα mediates prostate cancer cell death induced by combinatorial targeting of the androgen receptor
Summary of genes expression changes after treatment with bicalutamide, vorinostat, and the combination. LNCaP cells were treated with vehicle control, bicalutamide, vorinostat and bicalutamide and vorinostat in combination, and RNA was extracted at 6 h of treatment. Microarray analysis was performed on Affymetrix Human GeneChip 1.0 ST Arrays, with six biological replicates per sample. a Venn diagram of genes with mRNA levels significantly changed by vorinostat (light grey), bicalutamide (dark grey) or the doses of vorinostat and bicalutamide in combination (white), when compared with vehicle control. Circles represent both significantly up-regulated and significantly down-regulated genes over vehicle control, and sizes are proportional to the number of genes. b Numbers of genes significantly up-regulated and significantly down-regulated by each treatment when compared with vehicle control