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Table 2 Current chemotherapy regimensa

From: Randomized phase III trial of APF530 versus palonosetron in the prevention of chemotherapy-induced nausea and vomiting in a subset of patients with breast cancer receiving moderately or highly emetogenic chemotherapy

 

APF530

250 mg

APF530

500 mg

Palonosetron

0.25 mg

MEC regimens, n (%)

n = 149

n = 140

n = 134

 Docetaxel-trastuzumab

0

1 (0.7)

2 (1.5)

 Doxorubicin

1 (0.7)

1 (0.7)

1 (0.7)

 Cyclophosphamide-anthracycline

121 (81.2)

108 (77.1)

102 (76.1)

 Cyclophosphamide-docetaxel

7 (4.7)

7 (5.0)

13 (9.7)

 5-FU-cyclophosphamide-methotrexate

10 (6.7)

11 (7.9)

5 (3.7)

 Docetaxel-epirubicin

4 (2.7)

3 (2.1)

3 (2.2)

HEC regimens, n (%)

n = 60

n = 67

n = 58

 Cyclophosphamide-doxorubicin

2 (3.3)

3 (4.5)

0

 5-FU-cyclophosphamide-anthracycline

29 (48.3)

33 (49.3)

33 (56.9)

 Cyclophosphamide-docetaxel-doxorubicin

15 (25.0)

10 (14.9)

7 (12.1)

 Carboplatin-docetaxel-trastuzumab

5 (8.3)

5 (7.5)

5 (8.6)

 Carboplatin-docetaxel

2 (3.3)

5 (7.5)

4 (6.9)

 Carboplatin-paclitaxel

0

4 (6.0)

2 (3.4)

 Carboplatin-gemcitabine

1 (1.7)

2 (3.0)

1 (1.7)

  1. aReceived by 3 or more patients
  2. 5-FU 5-fluorouracil; HEC highly emetogenic chemotherapy; MEC moderately emetogenic chemotherapy