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Table 1 Anti-proliferative activity of Cisplatin (IV) prodrugs. Anti-proliferative activity was determined according to Materials and Methods. IC50s values of the different derivatives are in microM. Data shown are of representative experiment with CV below 15 % in all samples. Experiment was repeated three times with comparable outcome

From: Platinum (IV)-fatty acid conjugates overcome inherently and acquired Cisplatin resistant cancer cell lines: an in-vitro study

  IC50 (μM)
Compound A2780 A2780cisR K562
Cisplatin 1.3 19.2 5.2
Oxaliplatin 12.7 15.5 3.2
Carboplatin 16.8 109 ND
RJY1 >20 >20 34
RJY2 15.3 6 3.8
RJY3 >20 15 9.4
RJY4 20 7 3.9
RJY5 >20 >20 >20
RJY6 0.7 3.3 1.3
RJY9 >20 >20 >20
RJY10 19.2 >20 >20
RJY11 >20 >20 >20
RJY13 0.08 0.57 0.7
RJY18 14 2.1 0.85
RJY19 12.7 10 9.3