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Table 1 Anti-proliferative activity of Cisplatin (IV) prodrugs. Anti-proliferative activity was determined according to Materials and Methods. IC50s values of the different derivatives are in microM. Data shown are of representative experiment with CV below 15 % in all samples. Experiment was repeated three times with comparable outcome

From: Platinum (IV)-fatty acid conjugates overcome inherently and acquired Cisplatin resistant cancer cell lines: an in-vitro study

 

IC50 (μM)

Compound

A2780

A2780cisR

K562

Cisplatin

1.3

19.2

5.2

Oxaliplatin

12.7

15.5

3.2

Carboplatin

16.8

109

ND

RJY1

>20

>20

34

RJY2

15.3

6

3.8

RJY3

>20

15

9.4

RJY4

20

7

3.9

RJY5

>20

>20

>20

RJY6

0.7

3.3

1.3

RJY9

>20

>20

>20

RJY10

19.2

>20

>20

RJY11

>20

>20

>20

RJY13

0.08

0.57

0.7

RJY18

14

2.1

0.85

RJY19

12.7

10

9.3