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Fig. 5 | BMC Cancer

Fig. 5

From: METCAM/MUC18 is a novel tumor and metastasis suppressor for the human ovarian cancer SKOV3 cells

Fig. 5

Effect of huMETCAM/MUC18 expression on the in vivo tumorigenesis of SK-OV-3 clones/cells at the IP injection sites. Tumorigenicity of the METCAM clone 2D and the control (vector) clone 3D of SK-OV-3 was also determined by IP injection of 5 × 106 cells of the two clones in athymic nude mice. a Shows that the mice injected with the control (vector) clone 3D bore tumors and developed ascites in the intra-peritoneal cavity (#365-369), whereas the mice injected with the METCAM clone 2D did not bear any tumors and develop ascites in the intra-peritoneal cavity (#360-363). The bar shows the 1 cm mark. b Shows the final mean tumor weights of the two clones in the abdominal cavity, and c the final volumes of total ascites fluid and d the pelleted volume of ascites cells of both clones. P values were determined by analyzing all the data with the Student’s t test by using the 2-tailed distribution-type 1 method in (b) and the 1-tailed distribution-type 1 method in (c) and (d)

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